[HTML][HTML] Ejection of damaged mitochondria and their removal by macrophages ensure efficient thermogenesis in brown adipose tissue

M Rosina, V Ceci, R Turchi, C Li, N Borcherding… - Cell metabolism, 2022 - cell.com
Recent findings have demonstrated that mitochondria can be transferred between cells to
control metabolic homeostasis. Although the mitochondria of brown adipocytes comprise a …

Autoregulatory control of mitochondrial glutathione homeostasis

Y Liu, S Liu, A Tomar, FS Yen, G Unlu, N Ropek… - Science, 2023 - science.org
Mitochondria must maintain adequate amounts of metabolites for protective and biosynthetic
functions. However, how mitochondria sense the abundance of metabolites and regulate …

Mechanisms of mitochondrial ROS production in assisted reproduction: the known, the unknown, and the intriguing

JN Cobley - Antioxidants, 2020 - mdpi.com
The consensus that assisted reproduction technologies (ART), like in vitro fertilization, to
induce oxidative stress (ie, the known) belies how oocyte/zygote mitochondria—a major …

A Ca2+-sensor switch for tolerance to elevated salt stress in Arabidopsis

L Steinhorst, G He, LK Moore, S Schültke… - Developmental Cell, 2022 - cell.com
Excessive Na+ in soils inhibits plant growth. Here, we report that Na+ stress triggers primary
calcium signals specifically in a cell group within the root differentiation zone, thus forming a" …

Exploring the unmapped cysteine redox proteoform landscape

JN Cobley - American Journal of Physiology-Cell …, 2024 - journals.physiology.org
Cysteine redox proteoforms define the diverse molecular states that proteins with cysteine
residues can adopt. A protein with one cysteine residue must adopt one of two binary …

Oxidation of Atg3 and Atg7 mediates inhibition of autophagy

K Frudd, T Burgoyne, JR Burgoyne - Nature communications, 2018 - nature.com
Macroautophagy (autophagy) is a crucial cellular stress response for degrading defective
macromolecules and organelles, as well as providing bioenergetic intermediates during …

Identification of PSD-95 depalmitoylating enzymes

N Yokoi, Y Fukata, A Sekiya, T Murakami… - Journal of …, 2016 - Soc Neuroscience
Postsynaptic density (PSD)-95, the most abundant postsynaptic scaffolding protein, plays a
pivotal role in synapse development and function. Continuous palmitoylation cycles on PSD …

Mass-tag labeling reveals site-specific and endogenous levels of protein S-fatty acylation

A Percher, S Ramakrishnan, E Thinon… - Proceedings of the …, 2016 - National Acad Sciences
Fatty acylation of cysteine residues provides spatial and temporal control of protein function
in cells and regulates important biological pathways in eukaryotes. Although recent methods …

IDH3γ functions as a redox switch regulating mitochondrial energy metabolism and contractility in the heart

MS Nanadikar, AM Vergel Leon, J Guo… - Nature …, 2023 - nature.com
Redox signaling and cardiac function are tightly linked. However, it is largely unknown
which protein targets are affected by hydrogen peroxide (H2O2) in cardiomyocytes that …

Oxidation inhibits autophagy protein deconjugation from phagosomes to sustain MHC class II restricted antigen presentation

LA Ligeon, M Pena-Francesch, LD Vanoaica… - Nature …, 2021 - nature.com
Abstract LC3-associated phagocytosis (LAP) contributes to a wide range of cellular
processes and notably to immunity. The stabilization of phagosomes by the …