Arterial occlusive disease is the leading cause of death in Western countries. Core
contemporary therapies for this disease include angioplasties, stents, endarterectomies and …

It is anticipated that by 2040 neurodegeneration will affect 40 million people worldwide,
more than twice as many as today. The traditional neurocentric view holds that …

Inflammation plays an important role in cardiac injuries. Here, we examined the role of
miRNA in regulating inflammation and cardiac injury during myocardial infarction. We …

Senescent cells (SNCs) degenerate the fibrous cap that normally prevents atherogenic
plaque rupture, a leading cause of myocardial infarction and stroke. Here we explore the …

Muscle wasting in chronic kidney disease (CKD) begins with impaired insulin/IGF-1
signaling, causing abnormal protein metabolism. In certain models of muscle atrophy …

Cardiac fibrosis is primarily mediated by activated fibroblasts. However, cardiomyocytes
have also been implicated in facilitating the fibrotic response. We aimed to explore how …

Vascular smooth muscle cells (VSMCs) have critical functions in vascular diseases.
Haemodynamic factors are important regulators of VSMC functions in vascular …

Blood vessels are subjected to mechanical loads of pressure and flow, inducing smooth
muscle circumferential and endothelial shear stresses. The perception and response of …

After the creation of an autogenous lower extremity bypass graft, the vein must undergo a
series of dynamic structural changes to stabilize the arterial hemodynamic forces. These …

Rationale: Loss of fibulin-4 during embryogenesis results in perinatal lethality because of
aneurysm rupture, and defective elastic fiber assembly has been proposed as an underlying …