Virtually all cell types have the same DNA, yet each type exhibits its own cell-specific pattern
of gene expression. During the brief period of mitosis, the chromosomes exhibit changes in …

Adipogenesis is a process that differentiates new adipocytes from precursor cells and is
tightly regulated by several factors, including many transcription factors and various post …

Cellular differentiation requires extensive alterations in chromatin structure and function,
which is elicited by the coordinated action of chromatin and transcription factors. By contrast …

Mammalian SWI/SNF chromatin remodeling complexes move and evict nucleosomes at
gene promoters and enhancers to modulate DNA access. Although SWI/SNF subunits are …

Background Enhancers are essential in defining cell fates through the control of cell-type-
specific gene expression. Enhancer activation is a multi-step process involving chromatin …

The ARID1A subunit of SWI/SNF chromatin remodeling complexes is a potent tumor
suppressor. Here, a degron is applied to detect rapid loss of chromatin accessibility at …

Cellular senescence is a complex multifactorial biological phenomenon that plays essential
roles in aging, and aging-related diseases. During this process, the senescent cells undergo …

Diffuse midline gliomas (DMGs) including diffuse intrinsic pontine gliomas (DIPGs) bearing
lysine-to-methionine mutations in histone H3 at lysine 27 (H3K27M) are lethal childhood …

Enhancers are cis-regulatory elements that can stimulate gene expression from distance,
and drive precise spatiotemporal gene expression profiles during development. Functional …

Background Genes related to the SWItch/sucrose nonfermentable (SWI/SNF) chromatin
remodeling complex are frequently mutated across cancers. SWI/SNF-mutant tumors are …