High-throughput phenotyping for crop improvement in the genomics era
Tremendous progress has been made with continually expanding genomics technologies to
unravel and understand crop genomes. However, the impact of genomics data on crop …
unravel and understand crop genomes. However, the impact of genomics data on crop …
Pleiotropy in complex traits: challenges and strategies
Genome-wide association studies have identified many variants that each affects multiple
traits, particularly across autoimmune diseases, cancers and neuropsychiatric disorders …
traits, particularly across autoimmune diseases, cancers and neuropsychiatric disorders …
Efficiently controlling for case-control imbalance and sample relatedness in large-scale genetic association studies
In genome-wide association studies (GWAS) for thousands of phenotypes in large biobanks,
most binary traits have substantially fewer cases than controls. Both of the widely used …
most binary traits have substantially fewer cases than controls. Both of the widely used …
Detection and interpretation of shared genetic influences on 42 human traits
We performed a scan for genetic variants associated with multiple phenotypes by comparing
large genome-wide association studies (GWAS) of 42 traits or diseases. We identified 341 …
large genome-wide association studies (GWAS) of 42 traits or diseases. We identified 341 …
Evaluating phecodes, clinical classification software, and ICD-9-CM codes for phenome-wide association studies in the electronic health record
Objective To compare three groupings of Electronic Health Record (EHR) billing codes for
their ability to represent clinically meaningful phenotypes and to replicate known genetic …
their ability to represent clinically meaningful phenotypes and to replicate known genetic …
Systematic comparison of phenome-wide association study of electronic medical record data and genome-wide association study data
Candidate gene and genome-wide association studies (GWAS) have identified genetic
variants that modulate risk for human disease; many of these associations require further …
variants that modulate risk for human disease; many of these associations require further …
Network biology concepts in complex disease comorbidities
The co-occurrence of diseases can inform the underlying network biology of shared and
multifunctional genes and pathways. In addition, comorbidities help to elucidate the effects …
multifunctional genes and pathways. In addition, comorbidities help to elucidate the effects …
R PheWAS: data analysis and plotting tools for phenome-wide association studies in the R environment
Phenome-wide association studies (PheWAS) have been used to replicate known genetic
associations and discover new phenotype associations for genetic variants. This PheWAS …
associations and discover new phenotype associations for genetic variants. This PheWAS …
Trans-omics: how to reconstruct biochemical networks across multiple 'omic'layers
We propose 'trans-omic'analysis for reconstructing global biochemical networks across
multiple omic layers by use of both multi-omic measurements and computational data …
multiple omic layers by use of both multi-omic measurements and computational data …
Unravelling the human genome–phenome relationship using phenome-wide association studies
Advances in genotyping technology have, over the past decade, enabled the focused
search for common genetic variation associated with human diseases and traits. With the …
search for common genetic variation associated with human diseases and traits. With the …