Inflammation is a key driver in many pathological conditions such as allergy, cancer,
Alzheimer's disease, and many others, and the current state of available drugs prompted …

The Kelch-like ECH-associated protein 1-NF-E2-related factor 2 (KEAP1-NRF2) system
forms the major node of cellular and organismal defense against oxidative and electrophilic …

Antiviral strategies to inhibit Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-
CoV2) and the pathogenic consequences of COVID-19 are urgently required. Here, we …

Inflammation is the most common feature of many chronic diseases and complications, while
playing critical roles in carcinogenesis. Several studies have demonstrated that Nrf2 …

Systems medicine has a mechanism-based rather than a symptom-or organ-based
approach to disease and identifies therapeutic targets in a nonhypothesis-driven manner. In …

The Kelch-like ECH-associated protein 1 (KEAP1)/nuclear factor erythroid 2–related factor 2
(NRF2) pathway plays a physiologic protective role against xenobiotics and reactive oxygen …

Abstract The Keap1–Nrf2–ARE ((Kelch‐like ECH‐Associating protein 1) nuclear factor
erythroid 2 related factor 2‐antioxidant response element) pathway is one of the most …

Abstract Coronavirus disease-19 (COVID-19), a devastating respiratory illness caused by
SARS-associated coronavirus-2 (SARS-CoV-2), has already affected over 64 million people …

Transcription factor Nrf2 (NF-E2-related factor 2) is a master regulator of cellular responses
against environmental stresses. Nrf2 induces the expression of detoxification and …

The transcription factor Nrf2 is a critical regulator of inflammatory responses. If and how Nrf2
also affects cytosolic nucleic acid sensing is currently unknown. Here we identify Nrf2 as an …