The NF-κB transcription factor was discovered 30 years ago and has since emerged as the
master regulator of inflammation and immune homeostasis. It achieves this status by means …

The central role of Ca 2+ signaling in the development of functional immunity and tolerance
is well established. These signals are initiated by antigen binding to cognate receptors on …

Nuclear factor (NF)-κB has evolved as a latent, inducible family of transcription factors
fundamental in the control of the inflammatory response. The transcription of hundreds of …

Since 1998, cyclic mortality events in common eiders (Somateria mollissima), numbering in
the hundreds to thousands of dead birds, have been documented along the coast of Cape …

Phosphorylation of NF-κB plays an important role in modulating transcriptional activity of NF-
κB independently of inhibitor of κB (IκB) proteins. For the p65 subunit, multiple …

Isozyme-specific post-translational regulation fine tunes signaling events. However,
redundancy in sequence or activity renders links between isozyme-specific modifications …

Orientia tsutsugamushi causes scrub typhus, a potentially fatal infection that threatens over
one billion people. Nuclear translocation of the transcription factor, NF-κB, is the central …

The nuclear organelle, the nucleolus, plays a critical role in stress response and the
regulation of cellular homeostasis. P53 as a downstream effector of nucleolar stress is well …

Signals and posttranslational modifications regulating the decapping step in mRNA
degradation pathways are poorly defined. In this study we reveal the importance of K63 …

The nuclear factor κB (NF-κB) signaling pathway ubiquitously controls cell growth and
survival in basic conditions as well as rapid resetting of cellular functions following …