SARS-CoV-2 infection is characterized by a protean clinical picture that can range from
asymptomatic patients to life-threatening conditions. Severe COVID-19 patients often display …

The control over iron availability is crucial under homeostatic conditions and even more in
the case of an infection. This results from diverse properties of iron: first, iron is an important …

Macrophages and neutrophils play a decisive role in host responses to intracellular bacteria
including the agent of tuberculosis (TB), M ycobacterium tuberculosis as they represent the …

Over 30 million people suffer from the consequences of ischemic stroke. The precise
molecular mechanism of neuronal damage during ischemic stroke remains unclear; …

Abstract Thioredoxins (Trxs), glutaredoxins (Grxs), and peroxiredoxins (Prxs) have been
characterized as electron donors, guards of the intracellular redox state, and “antioxidants” …

Background Over the last few years, accumulating data have implicated a role for ferritin as
a signaling molecule and direct mediator of the immune system. Hyperferritinemia is …

Anemia is very common in patients with inflammatory disorders. Its prevalence is associated
with severity of the underlying disease, and it negatively affects quality of life and cardio …

Production of minute concentrations of superoxide (O 2 radical dot−) and nitrogen monoxide
(nitric oxide, NO radical dot) plays important roles in several aspects of cellular signaling …

Iron regulatory proteins 1 and 2 (IRP1 and IRP2) post-transcriptionally control the
expression of several mRNAs encoding proteins of iron, oxygen and energy metabolism …

The iron storage protein, ferritin, plays a key role in iron metabolism. Its ability to sequester
the element gives ferritin the dual functions of iron detoxification and iron reserve. The …