Are fibrinaloid microclots a cause of autoimmunity in Long Covid and other post-infection diseases?
DB Kell, E Pretorius - Biochemical Journal, 2023 - portlandpress.com
It is now well established that the blood-clotting protein fibrinogen can polymerise into an
anomalous form of fibrin that is amyloid in character; the resultant clots and microclots entrap …
anomalous form of fibrin that is amyloid in character; the resultant clots and microclots entrap …
The structure of the infectious prion protein: experimental data and molecular models
JR Requena, H Wille - Prion, 2014 - Taylor & Francis
The structures of the infectious prion protein, PrPSc, and that of its proteolytically truncated
variant, PrP 27–30, have evaded experimental determination due to their insolubility and …
variant, PrP 27–30, have evaded experimental determination due to their insolubility and …
Prion disease blood test using immunoprecipitation and improved quaking-induced conversion
CD Orrú, JM Wilham, LD Raymond, F Kuhn… - MBio, 2011 - Am Soc Microbiol
ABSTRACT A key challenge in managing transmissible spongiform encephalopathies
(TSEs) or prion diseases in medicine, agriculture, and wildlife biology is the development of …
(TSEs) or prion diseases in medicine, agriculture, and wildlife biology is the development of …
Mutant prion protein expression causes motor and memory deficits and abnormal sleep patterns in a transgenic mouse model
A familial form of Creutzfeldt-Jakob disease (CJD) is linked to the D178N/V129 prion protein
(PrP) mutation. Tg (CJD) mice expressing the mouse homolog of this mutant PrP synthesize …
(PrP) mutation. Tg (CJD) mice expressing the mouse homolog of this mutant PrP synthesize …
Transgenic fatal familial insomnia mice indicate prion infectivity-independent mechanisms of pathogenesis and phenotypic expression of disease
I Bouybayoune, S Mantovani, F Del Gallo… - PLoS …, 2015 - journals.plos.org
Fatal familial insomnia (FFI) and a genetic form of Creutzfeldt-Jakob disease (CJD178) are
clinically different prion disorders linked to the D178N prion protein (PrP) mutation. The …
clinically different prion disorders linked to the D178N prion protein (PrP) mutation. The …
Pharmacological agents targeting the cellular prion protein
Prion diseases are associated with the conversion of the cellular prion protein (PrPC), a
glycoprotein expressed at the surface of a wide variety of cell types, into a misfolded …
glycoprotein expressed at the surface of a wide variety of cell types, into a misfolded …
Propagation of PrPSc in mice reveals impact of aggregate composition on prion disease pathogenesis
SC Chang, S Hannaoui, MI Arifin, YH Huang… - Communications …, 2023 - nature.com
Infectious prions consist of PrPSc, a misfolded, aggregation-prone isoform of the host's prion
protein. PrPSc assemblies encode distinct biochemical and biological properties. They …
protein. PrPSc assemblies encode distinct biochemical and biological properties. They …
Cryo-immunogold electron microscopy for prions: toward identification of a conversion site
Prion diseases are caused by accumulation of an abnormally folded isoform (PrPSc) of the
cellular prion protein (PrPC). The subcellular distribution of PrPSc and the site of its …
cellular prion protein (PrPC). The subcellular distribution of PrPSc and the site of its …
Aggregated, wild-type prion protein causes neurological dysfunction and synaptic abnormalities
The neurotoxic forms of the prion protein (PrP) that cause neurodegeneration in prion
diseases remain to be conclusively identified. Considerable evidence points to the …
diseases remain to be conclusively identified. Considerable evidence points to the …
N-terminal regions of prion protein: Functions and roles in prion diseases
H Hara, S Sakaguchi - International journal of molecular sciences, 2020 - mdpi.com
The normal cellular isoform of prion protein, designated PrPC, is constitutively converted to
the abnormally folded, amyloidogenic isoform, PrPSc, in prion diseases, which include …
the abnormally folded, amyloidogenic isoform, PrPSc, in prion diseases, which include …