Pathogenesis of preeclampsia and therapeutic approaches targeting the placenta

MK Jena, NR Sharma, M Petitt, D Maulik, NR Nayak - Biomolecules, 2020 - mdpi.com
Preeclampsia (PE) is a serious pregnancy complication, affecting about 5–7% of
pregnancies worldwide and is characterized by hypertension and damage to multiple …

Animal models of preeclampsia: causes, consequences, and interventions

KL Gatford, PH Andraweera, CT Roberts, AS Care - Hypertension, 2020 - Am Heart Assoc
Preeclampsia is a common pregnancy complication, affecting 2% to 8% of pregnancies
worldwide, and is an important cause of both maternal and fetal morbidity and mortality …

Causes and consequences of the dysregulated maternal renin-angiotensin system in preeclampsia

ER Lumbers, SJ Delforce, AL Arthurs… - Frontiers in …, 2019 - frontiersin.org
A healthy pregnancy outcome depends on the activation of the renin-angiotensin-
aldosterone system (RAAS) as a regulated, integrated response to the growing demands of …

The complement system and preeclampsia

JF Regal, RM Burwick, SD Fleming - Current hypertension reports, 2017 - Springer
Abstract Purpose of Review Preeclampsia affects 3–4% of pregnancies with few treatment
options to reduce maternal and fetal harm. Recent evidence that targeting the complement …

Rodent models of hypertension

HA Jama, RR Muralitharan, C Xu… - British Journal of …, 2022 - Wiley Online Library
Elevated blood pressure (BP), or hypertension, is the main risk factor for cardiovascular
disease. As a multifactorial and systemic disease that involves multiple organs and systems …

Trophoblast-specific expression of Hif-1α results in preeclampsia-like symptoms and fetal growth restriction

RE Albers, MR Kaufman, BV Natale, C Keoni… - Scientific Reports, 2019 - nature.com
The placenta is an essential organ that is formed during pregnancy and its proper
development is critical for embryonic survival. While several animal models have been …

[HTML][HTML] Arginine vasopressin infusion is sufficient to model clinical features of preeclampsia in mice

JA Sandgren, G Deng, DW Linggonegoro… - JCI insight, 2018 - ncbi.nlm.nih.gov
Copeptin, a marker of arginine vasopressin (AVP) secretion, is elevated throughout human
pregnancies complicated by preeclampsia (PE), and AVP infusion throughout gestation is …

The potent antioxidant MitoQ protects against preeclampsia during late gestation but increases the risk of preeclampsia when administered in early pregnancy

Y Yang, P Xu, F Zhu, J Liao, Y Wu, M Hu… - Antioxidants & Redox …, 2021 - liebertpub.com
Aims: Although preeclampsia (PE) has been attributed to excessive oxidative stress (OS) in
the placenta, mild antioxidants failed to prevent PE in clinical trials. As mitochondria are a …

Preeclampsia history and postpartum risk of cerebrovascular disease and cognitive impairment: Potential mechanisms

AG Beckett, MD McFadden, JP Warrington - Frontiers in Physiology, 2023 - frontiersin.org
Hypertensive disorders of pregnancy such as preeclampsia, eclampsia, superimposed
preeclampsia, and gestational hypertension are major causes of fetal and maternal …

Gold nanoparticle biodistribution in pregnant mice following intravenous administration varies with gestational age

S N'Dea, KM Nelson, MN Dang, JP Gleghorn… - … , Biology and Medicine, 2021 - Elsevier
The use of nanoparticles (NPs) to deliver therapeutics to reproductive organs is an emerging
approach to safely and effectively treat mothers and babies facing pregnancy complications …