Eighteen nucleic acid therapeutics have been approved for treatment of various diseases in
the last 25 years. Their modes of action include antisense oligonucleotides (ASOs), splice …

Oligonucleotide-based therapeutics have made rapid progress in the clinic for treatment of a
variety of disease indications. Unmodified oligonucleotides are polyanionic macromolecules …

The field of RNA nanotechnology has advanced rapidly during the past decade. A variety of
programmable RNA nanoparticles with defined shape, size, and stoichiometry have been …

The breadth of structure and function displayed by the molecules of biology is remarkable.
Considering that there are only three major biopolymer backbones (proteins, ribonucleic …

Antisense agents are valuable tools to inhibit the expression of a target gene in a sequence‐
specific manner, and may be used for functional genomics, target validation and therapeutic …

We describe here a new method for highly efficient detection of microRNAs by northern blot
analysis using LNA (locked nucleic acid)-modified oligonucleotides. In order to exploit the …

Locked nucleic acid is an RNA derivative in which the ribose ring is constrained by a
methylene linkage between the 2′-oxygen and the 4′-carbon. This conformation …

The design of antisense oligonucleotides containing locked nucleic acids (LNA) was
optimized and compared to intensively studied DNA oligonucleotides, phosphorothioates …

Therapeutic application of the recently discovered small interfering RNA (siRNA) gene
silencing phenomenon will be dependent on improvements in molecule bio-stability …

Locked nucleic acid (LNA) is a nucleic acid analogue that displays unprecedented
hybridization affinity towards complementary DNA and RNA. Structural studies have shown …