The discovery of interleukin-2 (IL-2) changed the molecular understanding of how the
immune system is controlled. IL-2 is a pleiotropic cytokine, and dissecting the signaling …

IL-2 was first identified as a growth factor capable of driving the expansion of activated
human T cell populations. In the more than 40 years since its discovery, a tremendous …

The common cytokine receptor γ chain, γ c, is a component of the receptors for interleukin-2
(IL-2), IL-4, IL-7, IL-9, IL-15, and IL-21. Mutation of the gene encoding γ c results in X-linked …

Interleukin-2 (IL-2) is a pleiotropic cytokine produced after antigen activation that plays
pivotal roles in the immune response. Discovered as a T cell growth factor, IL-2 additionally …

The immunostimulatory cytokine interleukin-2 (IL-2) is a growth factor for a wide range of
leukocytes, including T cells and natural killer (NK) cells,,. Considerable effort has been …

Interleukin-2 (IL-2), the first of a series of lymphocytotrophic hormones to be recognized and
completely characterized, is pivotal for the generation and regulation of the immune …

Summary The lnterleukln-2 (IL-2) receptor y chain (IL-S&) is a component of high and
Intermediate affinity IL-2 receptors that is required to achieve full ligand binding affinity and …

We have deduced the entire 1,370-amino-acid sequence of the human insulin receptor
precursor from a single complementary DNA clone. The precursor starts with a 27-amino …

We describe the isolation, characterization, and sequence of cDNA clones encoding one
subunit of the complex of membrane glycoproteins that forms part of the transmembrane …

In mice lacking the interleukin-2 receptor β chain (IL-2Rβ), T cells were shown to be
spontaneously activated, resulting in exhaustive differentiation of B cells into plasma cells …