A comprehensive review of rosmarinic acid: from phytochemistry to pharmacology and its new insight

H Guan, W Luo, B Bao, Y Cao, F Cheng, S Yu, Q Fan… - Molecules, 2022 - mdpi.com
Polyphenolic acids are the widely occurring natural products in almost each herbal plant,
among which rosmarinic acid (RA, C18H16O8) is well-known, and is present in over 160 …

Melissa officinalis L.–A review of its traditional uses, phytochemistry and pharmacology

A Shakeri, A Sahebkar, B Javadi - Journal of ethnopharmacology, 2016 - Elsevier
Ethnopharmacological relevance Melissa officinalis L. is a medicinal plant that has long
been used in different ethno-medical systems especially in the European Traditional …

Rosmarinic acid–human pharmacokinetics and health benefits

M Hitl, N Kladar, N Gavarić, B Božin - Planta medica, 2021 - thieme-connect.com
Rosmarinic acid is a phenolic compound commonly found in the Lamiaceae (Labiateae)
plant species. It is considered responsible for a wide spectrum of biological and …

Review on rosmarinic acid extraction, fractionation and its anti-diabetic potential

YL Ngo, CH Lau, LS Chua - Food and Chemical Toxicology, 2018 - Elsevier
Rosmarinic acid is a bioactive phytochemical that can be found in many herbs as
ethnomedicines. It possesses remarkable pharmacological activities, and thus leading to its …

[Retracted] Phytochemical Constituents, Biological Activities, and Health‐Promoting Effects of the Melissa officinalis

J Sharifi-Rad, C Quispe, J Herrera-Bravo… - Oxidative Medicine …, 2021 - Wiley Online Library
Medicinal plants are being used worldwide for centuries for their beneficial properties. Some
of the most popular medicinal plants belong to the Melissa genus, and different health …

The effects of lemon balm (Melissa officinalis L.) on depression and anxiety in clinical trials: A systematic review and meta‐analysis

J Ghazizadeh, S Sadigh‐Eteghad, W Marx… - Phytotherapy …, 2021 - Wiley Online Library
A systematic review and a meta‐analytic approach were considered to investigate the
effects of lemon balm as a medicinal herb on anxiety and depression in clinical trials and its …

[HTML][HTML] Rosmarinic acid-induced apoptosis and cell cycle arrest in triple-negative breast cancer cells

SS Messeha, NO Zarmouh, A Asiri… - European journal of …, 2020 - Elsevier
Rosmarinic acid (RA) is a polyphenolic compound with various pharmacological properties,
including, anti-inflammatory, immunomodulatory, and neuroprotective, as well as having …

Alzheimer's disease as oligomeropathy

K Ono - Neurochemistry international, 2018 - Elsevier
Alzheimer's disease (AD) is the most common age-related neurodegenerative disorder and
is characterized by pathological aggregates of amyloid β-protein (Aβ) and tau protein. On …

Safety and efficacy of Melissa officinalis extract containing rosmarinic acid in the prevention of Alzheimer's disease progression

M Noguchi-Shinohara, K Ono, T Hamaguchi, T Nagai… - Scientific reports, 2020 - nature.com
We conducted a randomized placebo-controlled double-blind 24-week trial using Melissa
officinalis (M. officinalis) extract richly containing rosmarinic acid (RA) on patients with mild …

Subcritical Water Extraction of Rosmarinic Acid from Lemon Balm (Melissa officinalis L.) and Its Effect on Plant Cell Wall Constituents

A Atanasova, A Petrova, D Teneva, M Ognyanov… - Antioxidants, 2023 - mdpi.com
Rosmarinic acid (RA), an ester of caffeic acid and 3, 4-dihydroxyphenyllactic acid, is a potent
radical scavenger, a chelator of prooxidant ions, and an inhibitor of lipid peroxidation. RA …