Modern haemophilia care

E Berntorp, AD Shapiro - The Lancet, 2012 - thelancet.com
Haemophilia care has undergone substantial improvements during the past 40–50 years.
Early clotting factor concentrates were not sufficiently refined to enable self-administered …

Genetic modifications of pigs for medicine and agriculture

JJ Whyte, RS Prather - Molecular reproduction and …, 2011 - Wiley Online Library
Genetically modified swine hold great promise in the fields of agriculture and medicine.
Currently, these swine are being used to optimize production of quality meat, to improve our …

Long-term intravenous treatment of Pompe disease with recombinant human α-glucosidase from milk

JMP Van den Hout, JHJ Kamphoven, LPF Winkel… - …, 2004 - publications.aap.org
Objective. Recent reports warn that the worldwide cell culture capacity is insufficient to fulfill
the increasing demand for human protein drugs. Production in milk of transgenic animals is …

Transgenic animal bioreactors

LM Houdebine - Transgenic research, 2000 - Springer
The production of recombinant proteins is one of the major successes of biotechnology.
Animal cells are required to synthesize proteins with the appropriate post-translational …

Genetic engineering of fibrous proteins: spider dragline silk and collagen

CWP Foo, DL Kaplan - Advanced drug delivery reviews, 2002 - Elsevier
Various strategies have been employed to genetically engineer fibrous proteins. Two
examples, the subject of this review, include spider dragline silk from Nephila clavipes and …

The contribution of farm animals to human health

WA Kues, H Niemann - TRENDS in Biotechnology, 2004 - cell.com
Farm animals and their products have a longstanding and successful history of providing
significant contributions to human nutrition, clothing, facilitation of labour, research …

Precision editing of large animal genomes

DF Carlson, MW Walton, SC Fahrenkrug, PB Hackett - Advances in …, 2012 - Elsevier
Transgenic animals are an important source of protein and nutrition for most humans and
will play key roles in satisfying the increasing demand for food in an ever-increasing world …

Application of transgenesis in livestock for agriculture and biomedicine

H Niemann, WA Kues - Animal reproduction science, 2003 - Elsevier
Microinjection of foreign DNA into pronuclei of a fertilized oocyte has predominantly been
used for the generation of transgenic livestock. This technology works reliably, but is …

Expression systems and species used for transgenic animal bioreactors

Y Wang, S Zhao, L Bai, J Fan… - BioMed Research …, 2013 - Wiley Online Library
Transgenic animal bioreactors can produce therapeutic proteins with high value for
pharmaceutical use. In this paper, we compared different systems capable of producing …

Biopharmaceutical production in transgenic livestock

NS Rudolph - Trends in Biotechnology, 1999 - cell.com
The production of recombinant human proteins in the milk of transgenic dairy animals offers
a safe, renewable source of commercially important proteins that cannot be produced as …