Upon receipt in the dorsal horn (DH) of the spinal cord, nociceptive (pain-signalling)
information from the viscera, skin and other organs is subject to extensive processing by a …

Chronic pain conditions are multifactorial disorders with a high frequency in the population.
Their pathophysiology is often unclear, and treatment is inefficient. During the last 20 years …

It is generally acknowledged that humans display highly variable sensitivity to pain,
including variable responses to identical injuries or pathologies. The possible contribution of …

Neuropathic pain is defined aspain initiated or caused by a primary lesion or dysfunction in
the nervous system'. 94 The spectrum of neuropathic pain covers a variety of disease states …

Pain is an immense clinical and societal challenge, and the key to understanding and
treating it is variability. Robust interindividual differences are consistently observed in pain …

Pain has often been regarded merely as a symptom that serves as a passive warning signal
of an underlying disease process. Using this model, the goal of treatment has been to …

The underlying bases of the considerable interindividual variability in pain-related traits are
starting to be revealed. Although the relative importance of genes versus experience in …

The aim of the present investigation was to describe and validate an electronic mechanical
test for quantification of the intensity of inflammatory nociception in mice. The electronic …

It has been appreciated for some time that the sexes can differ in their sensitivity to pain and
its inhibition. Both the human and rodent literatures remain quite contentious, with many …

Inflammation refers to a complex set of mechanisms by which tissues respond to injury and
infection. Among the many soluble mediators associated with this process, cytokines are …