Fundamentals and developments in fluorescence-guided cancer surgery

JSD Mieog, FB Achterberg, A Zlitni… - Nature reviews Clinical …, 2022 - nature.com
Fluorescence-guided surgery using tumour-targeted imaging agents has emerged over the
past decade as a promising and effective method of intraoperative cancer detection. An …

Molecular imaging and disease theranostics with renal-clearable optical agents

P Cheng, K Pu - Nature Reviews Materials, 2021 - nature.com
Optical imaging in disease diagnosis and treatment benefits from high spatiotemporal
resolution and the availability of numerous optical agents. However, many optical imaging …

Activatable molecular probes for fluorescence-guided surgery, endoscopy and tissue biopsy

Y Zhang, G Zhang, Z Zeng, K Pu - Chemical Society Reviews, 2022 - pubs.rsc.org
The real-time, dynamic optical visualization of lesions and margins ensures not only
complete resection of the malignant tissues but also better preservation of the vital …

Near‐infrared‐II molecular dyes for cancer imaging and surgery

S Zhu, R Tian, AL Antaris, X Chen, H Dai - Advanced Materials, 2019 - Wiley Online Library
Fluorescence bioimaging affords a vital tool for both researchers and surgeons to
molecularly target a variety of biological tissues and processes. This review focuses on …

Early detection of pancreatic cancer

SP Pereira, L Oldfield, A Ney, PA Hart… - The lancet …, 2020 - thelancet.com
Pancreatic ductal adenocarcinoma is most frequently detected at an advanced stage. Such
late detection restricts treatment options and contributes to a dismal 5-year survival rate of 3 …

Synthetic biomarkers: a twenty-first century path to early cancer detection

GA Kwong, S Ghosh, L Gamboa, C Patriotis… - Nature Reviews …, 2021 - nature.com
Detection of cancer at an early stage when it is still localized improves patient response to
medical interventions for most cancer types. The success of screening tools such as cervical …

Recent progresses in small-molecule enzymatic fluorescent probes for cancer imaging

HW Liu, L Chen, C Xu, Z Li, H Zhang… - Chemical Society …, 2018 - pubs.rsc.org
Abnormal enzymatic activities are directly related to the development of cancers. Identifying
the location and expression levels of these enzymes in live cancer cells have considerable …

Multiplexed imaging in oncology

C Andreou, R Weissleder, MF Kircher - Nature Biomedical Engineering, 2022 - nature.com
In oncology, technologies for clinical molecular imaging are used to diagnose patients,
establish the efficacy of treatments and monitor the recurrence of disease. Multiplexed …

Renal clearable catalytic gold nanoclusters for in vivo disease monitoring

CN Loynachan, AP Soleimany, JS Dudani, Y Lin… - Nature …, 2019 - nature.com
Ultrasmall gold nanoclusters (AuNCs) have emerged as agile probes for in vivo imaging, as
they exhibit exceptional tumour accumulation and efficient renal clearance properties …

Latest developments in molecular tracers for fluorescence image-guided cancer surgery

S Hernot, L van Manen, P Debie, JSD Mieog… - The lancet …, 2019 - thelancet.com
Real-time intraoperative guidance is essential during oncological surgery for complete and
safe tumour resection. Fluorescence imaging in the near-infrared spectrum has shown …