Glioblastoma multiforme (GBM) is the most common and aggressive malignant brain tumor
of the central nervous system and has a very poor prognosis. The current standard of care …

Since the discovery in 1796 by Edward Jenner of vaccinia virus as a way to prevent and
finally eradicate smallpox, the concept of using a virus to fight another virus has evolved into …

Current glioblastoma therapies are insufficient to prevent tumor recurrence and eventual
death. Here, we describe a method to treat malignant glioma by nonviral DNA delivery using …

Oncolytic virotherapy is a promising form of gene therapy for cancer, employing nature's own
agents to find and destroy malignant cells. The purpose of this review is to provide an …

Glioblastoma multiforme is the most common primary malignant tumor of the central nervous
system. Despite new insights into glioblastoma pathophysiology, the prognosis for patients …

A phase I trial of an engineered poliovirus for the treatment of recurrent glioblastoma (GBM)
has attracted attention due to 8 survivors reaching the 24-month and 5 reaching the 36 …

The principle of using suicide genes for gene directed enzyme prodrug therapy (GDEPT) of
cancer has gained increasing significance during the 20 years since its inception. The astute …

Retroviral replicating vectors (RRVs) are a nonlytic alternative to oncolytic replicating viruses
as anticancer agents, being selective both for dividing cells and for cells that have defects in …

Patients with the most common and aggressive form of high-grade glioma, glioblastoma
multiforme, have poor prognosis and few treatment options. In 2 immunocompetent mouse …

Malignant brain cancer treatment is limited by a number of barriers, including the blood–
brain barrier, transport within the brain interstitium, difficulties in delivering therapeutics …