An established mechanistic and clinical role for prophylaxis against paediatric respiratory
infections by nonspecific immunomodulators exists. Clinical trials underway promise to …

Among the many areas being revolutionized by the recent introduction of culture-
independent microbial identification techniques is investigation of the relationship between …

Background Microbial interventions against allergic asthma have robust epidemiologic
underpinnings and the potential to recalibrate disease-inducing immune responses. Oral …

Asthma is a heterogeneous disease, with multiple underlying inflammatory pathways and
structural airway abnormalities that impact disease persistence and severity. Recent …

Wheezing and asthma are a growing cause of morbidity in children and adults. Treatment is
aimed at prevention of disease exacerbations and preservation of lung function. Respiratory …

Allergic diseases typically begin in early life and can impose a heavy burden on children
and their families. Effective preventive measures are currently unavailable but may be …

Secondary bacterial infections following influenza infection are a pressing problem facing
respiratory medicine. Although antibiotic treatment has been highly successful over recent …

Critical evidence has been recently generated that supports not only the essential role that
early life events and exposures play in asthma inception but also the childhood roots of …

Recent studies of the natural history of asthma have shifted attention toward viral respiratory
tract illness in early life as a major risk factor associated with the development of the most …

Respiratory syncytial virus (RSV) is a seasonal pathogen responsible for the highest
percentage of viral bronchiolitis in pediatric patients. There are currently no vaccine …