The WHO recognizes human African trypanosomiasis, Chagas disease and the
leishmaniases as neglected tropical diseases. These diseases are caused by parasitic …

Pyridazinones have drawn a substantial attention within the field of research analysis and
development. The moiety is a subject matter of intensive research because of its wide …

Cryptosporidium parvum and C. hominis are parasites that cause life-threatening diarrhea in
children and immunocompromised people. There is only one approved treatment that is …

Abstract The Pathogen Box is a 400‐strong collection of drug‐like compounds, selected for
their potential against several of the world's most important neglected tropical diseases …

The unicellular parasite Trypanosoma brucei is transmitted between mammals by tsetse
flies. Following the discovery that flagellar phosphodiesterase PDEB1 is required for …

Protein kinase A (PKA), the main effector of cAMP in eukaryotes, is a paradigm for the
mechanisms of ligand-dependent and allosteric regulation in signalling. Here we report the …

Background Reliance on just one drug to treat the prevalent tropical disease,
schistosomiasis, spurs the search for new drugs and drug targets. Inhibitors of human cyclic …

Several trypanosomatid cyclic nucleotide phosphodiesterases (PDEs) possess a unique,
parasite-specific cavity near the ligand-binding region that is referred to as the P-pocket …

As there is a continuous need for novel anti-infectives, the present study aimed to fuse two
modes of action into a novel 3-nitroimidazo [1, 2-b] pyridazine scaffold to improve …

The development of new therapeutics targeting enzymes involved in epigenetic pathways
such as histone modification and DNA methylation has received a lot of attention …