Photoreceptor phosphodiesterase (PDE6): activation and inactivation mechanisms during visual transduction in rods and cones

RH Cote - Pflügers Archiv-European Journal of Physiology, 2021 - Springer
Rod and cone photoreceptors of the vertebrate retina utilize cGMP as the primary
intracellular messenger for the visual signaling pathway that converts a light stimulus into an …

The discovery of the ability of rod photoreceptors to signal single photons

EN Pugh Jr - Journal of General Physiology, 2018 - rupress.org
Vertebrate rod photoreceptors evolved the astonishing ability to respond reliably to single
photons. In parallel, the proximate neurons of the visual system evolved the ability to reliably …

Diversity and evolution of frog visual opsins: spectral tuning and adaptation to distinct light environments

RK Schott, MK Fujita, JW Streicher… - Molecular biology …, 2024 - academic.oup.com
Visual systems adapt to different light environments through several avenues including
optical changes to the eye and neurological changes in how light signals are processed and …

Functional optical coherence tomography enables in vivo optoretinography of photoreceptor dysfunction due to retinal degeneration

TH Kim, B Wang, Y Lu, T Son, X Yao - Biomedical Optics Express, 2020 - opg.optica.org
Stimulus-evoked intrinsic optical signal (IOS), which occurs almost immediately after the
onset of retinal stimulus has been observed in retinal photoreceptors, promises to be a …

[HTML][HTML] Loss of cone function without degeneration in a novel Gnat2 knock-out mouse

KE Ronning, GP Allina, EB Miller, RJ Zawadzki… - Experimental eye …, 2018 - Elsevier
Rods and cones mediate visual perception over 9 log units of light intensities, with both
photoreceptor types contributing to a middle 3-log unit range that comprises most night-time …

Rod photoresponse kinetics limit temporal contrast sensitivity in mesopic vision

Y Umino, Y Guo, CK Chen, R Pasquale… - Journal of …, 2019 - Soc Neuroscience
The mammalian visual system operates over an extended range of ambient light levels by
switching between rod and cone photoreceptors. Rod-driven vision is sluggish, highly …

Transcriptional response to cold and fasting acclimation in Onychostoma macrolepis during the overwintering stage

N Gou, H Ji, W Wu, M Zhong, B Zhang - Comparative Biochemistry and …, 2021 - Elsevier
In this study, we investigated the transcriptome responses of the liver of Onychostoma
macrolepis in by RNA sequencing. The sampling process involved three groups: 1G (0 …

RBX2 maintains final retinal cell position in a DAB1-dependent and-independent fashion

CL Fairchild, K Hino, JS Han, AM Miltner… - …, 2018 - journals.biologists.com
The laminated structure of the retina is fundamental for the organization of the synaptic
circuitry that translates light input into patterns of action potentials. However, the molecular …

Visual temporal contrast sensitivity in the behaving mouse shares fundamental properties with human psychophysics

Y Umino, R Pasquale, E Solessio - Eneuro, 2018 - eneuro.org
The mammalian visual system has a remarkable capacity to detect differences in contrast
across time, which is known as temporal contrast sensitivity (TCS). Details of the underlying …

Temporal contrast sensitivity increases despite photoreceptor degeneration in a mouse model of retinitis pigmentosa

RL Pasquale, Y Guo, Y Umino, B Knox, E Solessio - eneuro, 2021 - eneuro.org
The detection of temporal variations in amplitude of light intensity, or temporal contrast
sensitivity (TCS), depends on the kinetics of rod photoresponse recovery …