Human lectins and their roles in viral infections

CP Mason, AW Tarr - Molecules, 2015 - mdpi.com
Innate recognition of virus proteins is an important component of the immune response to
viral pathogens. A component of this immune recognition is the family of lectins; pattern …

Mannose binding lectin gene 2 (rs1800450) missense variant may contribute to development and severity of COVID-19 infection

A Medetalibeyoglu, G Bahat, N Senkal, M Kose… - Infection, genetics and …, 2021 - Elsevier
Background/objectives COVID-19 followed a mortal course in some young patients without
any underlying factors, however, it followed a very benign course in some very older …

Serum mannose-binding lectin (MBL) gene polymorphism and low MBL levels are associated with neonatal sepsis and pneumonia

H Özkan, N Köksal, M Çetinkaya, S Çelebi… - Journal of …, 2012 - nature.com
Objective: The aim of this study was to determine the serum mannose-binding lectin (MBL)
levels and the frequency of MBL gene polymorphisms in infants with neonatal sepsis. Study …

Immunogenetic studies of the hepatitis C virus infection in an era of pan-genotype antiviral therapies-Effective treatment is coming

JH Ellwanger, V de Lima Kaminski… - Infection, Genetics and …, 2018 - Elsevier
What are the factors that influence human hepatitis C virus (HCV) infection, hepatitis status
establishment, and disease progression? Firstly, one has to consider the genetic …

Specific interaction of hepatitis C virus glycoproteins with mannan binding lectin inhibits virus entry

KS Brown, MJ Keogh, AM Owsianka, R Adair, AH Patel… - Protein & cell, 2010 - Springer
Mannan-binding lectin (MBL) is a soluble innate immune protein that binds to glycosylated
targets. MBL acts as an opsonin and activates complement, contributing to the destruction …

Mannose-binding lectin gene polymorphism and chronic hepatitis B infection in children

G Erdemir, TB Ozkan, T Ozgur, F Budak… - Saudi Journal of …, 2015 - journals.lww.com
Results: Homozygous codon 54 polymorphism of MBL was found significantly higher in
chronic hepatitis B patients than controls. Rate of the polymorphism was similar in all groups …

JC polyomavirus infection in candidates for kidney transplantation living in the Brazilian Amazon Region

FAF Melo, ACF Bezerra, BB Santana… - Memórias do Instituto …, 2013 - SciELO Brasil
This study evaluated the relative occurrences of BK virus (BKV) and JC virus (JCV)
infections in patients with chronic kidney disease (CKD). Urine samples were analysed from …

HBV Viral Load and Liver Enzyme Levels May Be Associated with the Wild MBL2 AA Genotype

TCF Moura, ESG Amoras, MS Araújo… - Mediators of …, 2017 - Wiley Online Library
The present study investigated the frequencies of rs1800450 (MBL⁎ B, G> A), rs1800451
(MBL⁎ C, G> A), and rs5030737 (MBL⁎ D, C> T) polymorphisms in exon 1 of the MBL2 …

MBL2 Genetic Variants in HCV Infection Susceptibility, Spontaneous Viral Clearance and Pegylated Interferon Plus Ribavirin Treatment Response

L Zupin, V Polesello, G Alberi… - Scandinavian …, 2016 - Wiley Online Library
Hepatitis C is disease that damages the liver, and it is caused by the hepatitis C virus (HCV).
The pathology became chronic in about 80% of the cases due to virus persistence in the …

Effects of mannose-binding lectin and mannose-binding lectin polymorphisms on treatment response in patients with chronic hepatitis C

S Kömür, A İNAL, A Ulu, B Kurtaran… - Turkish Journal of …, 2014 - avesis.cu.edu.tr
Background/Aims: The natural course and clinical outcome of hepatitis C virus (HCV)
infection is related to the interaction between HCV and the immune response of the host …