Single-cell RNA sequencing maps endothelial metabolic plasticity in pathological angiogenesis
Endothelial cell (EC) metabolism is an emerging target for anti-angiogenic therapy in tumor
angiogenesis and choroidal neovascularization (CNV), but little is known about individual …
angiogenesis and choroidal neovascularization (CNV), but little is known about individual …
The loss of cardiac SIRT3 decreases metabolic flexibility and proteostasis in an age-dependent manner
P Li, MF Newhardt, S Matsuzaki, C Eyster, A Pranay… - GeroScience, 2023 - Springer
SIRT3 is a longevity factor that acts as the primary deacetylase in mitochondria. Although
ubiquitously expressed, previous global SIRT3 knockout studies have shown primarily a …
ubiquitously expressed, previous global SIRT3 knockout studies have shown primarily a …
Transcription factor control of lymphatic quiescence and maturation of lymphatic neovessels in development and physiology
ZB Tabrizi, NS Ahmed, JL Horder, SJ Storr… - Frontiers in …, 2021 - frontiersin.org
The lymphatic system is a vascular system comprising modified lymphatic endothelial cells,
lymph nodes and other lymphoid organs. The system has diverse, but critical functions in …
lymph nodes and other lymphoid organs. The system has diverse, but critical functions in …
GLUT1 and PKM2 may be useful prognostic predictors in patients with non‑small cell lung cancer following curative R0 resection
R Ito, M Yashiro, T Tsukioka, N Izumi… - Oncology …, 2023 - spandidos-publications.com
Lung cancer has a poor prognosis despite recent progresses being made regarding its
treatment. In addition, there is a paucity of reliable and independent prognostic predictors for …
treatment. In addition, there is a paucity of reliable and independent prognostic predictors for …
Metabolomics revealed the influence of breast cancer on lymphatic endothelial cell metabolism, metabolic crosstalk, and lymphangiogenic signaling in co-culture
S Acevedo-Acevedo, DC Millar, AD Simmons… - Scientific reports, 2020 - nature.com
Breast cancer metastasis occurs via blood and lymphatic vessels. Breast cancer cells
'educate'lymphatic endothelial cells (LECs) to support tumor vascularization and growth …
'educate'lymphatic endothelial cells (LECs) to support tumor vascularization and growth …
Metabolic flexibility maintains proliferation and migration of FGFR signaling–deficient lymphatic endothelial cells
Metabolic flexibility is the capacity of cells to alter fuel metabolism in response to changes in
metabolic demand or nutrient availability. It is critical for maintaining cellular bioenergetics …
metabolic demand or nutrient availability. It is critical for maintaining cellular bioenergetics …
FGFR Signaling Coordinates the Balance Between Glycolysis and Fatty Acid β-Oxidation in Lymphatic Endothelial Cells
The balance between glycolysis and oxidative phosphorylation is believed to be critical for
maintaining cellular bioenergetics, yet the regulation of such balance in lymphatic …
maintaining cellular bioenergetics, yet the regulation of such balance in lymphatic …
[引用][C] Suehelay Acevedo‑Acevedo1Ε, Douglas C. Millar2, Aaron D. Simmons2, Peter Favreau3
PF Cobra, M Skala, SP Palecek - Scientific Reports, 2020
[引用][C] The loss of cardiac SIRT3 decreases metabolic flexibility and proteostasis in an age‑dependent manner
A Batushansky, C Kinter, K Subramani… - 2022 - europepmc.org
Accepted: 17 November 2022© The Author (s) 2022 amino acids in SIRT3cKO hearts
without concurrent increases in mTOR activity. Heavy water labeling experiments …
without concurrent increases in mTOR activity. Heavy water labeling experiments …