Vitiligo: a review
C Bergqvist, K Ezzedine - Dermatology, 2020 - karger.com
Vitiligo, a common depigmenting skin disorder, has an estimated prevalence of 0.5–2% of
the population worldwide. The disease is characterized by the selective loss of melanocytes …
the population worldwide. The disease is characterized by the selective loss of melanocytes …
Mechanisms of melanocyte death in vitiligo
J Chen, S Li, C Li - Medicinal Research Reviews, 2021 - Wiley Online Library
Vitiligo is an autoimmune depigment disease results from extensive melanocytes
destruction. The destruction of melanocyte is thought to be of multifactorial causation …
destruction. The destruction of melanocyte is thought to be of multifactorial causation …
[HTML][HTML] A single-cell atlas of chromatin accessibility in the human genome
Current catalogs of regulatory sequences in the human genome are still incomplete and lack
cell type resolution. To profile the activity of gene regulatory elements in diverse cell types …
cell type resolution. To profile the activity of gene regulatory elements in diverse cell types …
Complex genetic signatures in immune cells underlie autoimmunity and inform therapy
We report on the influence of~ 22 million variants on 731 immune cell traits in a cohort of
3,757 Sardinians. We detected 122 significant (P< 1.28× 10− 11) independent association …
3,757 Sardinians. We detected 122 significant (P< 1.28× 10− 11) independent association …
Interpreting type 1 diabetes risk with genetics and single-cell epigenomics
Genetic risk variants that have been identified in genome-wide association studies of
complex diseases are primarily non-coding. Translating these risk variants into mechanistic …
complex diseases are primarily non-coding. Translating these risk variants into mechanistic …
[HTML][HTML] Polygenic basis and biomedical consequences of telomere length variation
Telomeres, the end fragments of chromosomes, play key roles in cellular proliferation and
senescence. Here we characterize the genetic architecture of naturally occurring variation in …
senescence. Here we characterize the genetic architecture of naturally occurring variation in …
[HTML][HTML] The polygenic and monogenic basis of blood traits and diseases
Blood cells play essential roles in human health, underpinning physiological processes
such as immunity, oxygen transport, and clotting, which when perturbed cause a significant …
such as immunity, oxygen transport, and clotting, which when perturbed cause a significant …
A genome-wide transcriptomic analysis of protein-coding genes in human blood cells
INTRODUCTION Blood is the predominant source for molecular analyses in humans, both in
clinical and research settings, and is the target for many therapeutic strategies, emphasizing …
clinical and research settings, and is the target for many therapeutic strategies, emphasizing …
Vitiligo: a focus on pathogenesis and its therapeutic implications
C Bergqvist, K Ezzedine - The Journal of dermatology, 2021 - Wiley Online Library
Vitiligo is the most common depigmenting disorder affecting 0.1%–2% of the population
worldwide. The characteristic white patches result from the selective loss of melanocytes …
worldwide. The characteristic white patches result from the selective loss of melanocytes …
[HTML][HTML] Update on the pathogenesis of vitiligo
HZ Marchioro, CCS Castro, VM Fava… - Anais Brasileiros de …, 2022 - SciELO Brasil
Vitiligo is a complex disease whose pathogenesis results from the interaction of genetic
components, metabolic factors linked to cellular oxidative stress, melanocyte adhesion to the …
components, metabolic factors linked to cellular oxidative stress, melanocyte adhesion to the …