Cellular senescence, a process in which a cell exits the cell cycle in response to stressors, is
one of the hallmarks of aging. Senescence and the senescence-associated secretory …

Dietary restriction (DR) protocols frequently employ intermittent fasting. Following a period of
fasting, meal consumption increases lipogenic gene expression, including that of NADPH …

Restricting the intake of protein or the branched-chain amino acid isoleucine promotes
healthspan and extends lifespan in young or adult mice. However, their effects when …

Dietary restriction promotes resistance to surgical stress in multiple organisms.
Counterintuitively, current medical protocols recommend short-term carbohydrate-rich drinks …

Suboptimal nutrition is a leading cause of cardiometabolic disease and mortality. Biological
sex is a variable that influences individual responses to dietary components and may …

In defiance of the paradigm that calories from all sources are equivalent, we and others have
shown that dietary protein is a dominant regulator of healthy aging. The restriction of protein …

A growing number of geroprotectors have demonstrated healthspan extension in young
animals, but the effectiveness of these therapies when commenced in midlife or later has …