Multiscale simulations of biological membranes: the challenge to understand biological phenomena in a living substance

G Enkavi, M Javanainen, W Kulig, T Róg… - Chemical …, 2019 - ACS Publications
Biological membranes are tricky to investigate. They are complex in terms of molecular
composition and structure, functional over a wide range of time scales, and characterized by …

[HTML][HTML] Cytochrome b6f–Orchestrator of photosynthetic electron transfer

LA Malone, MS Proctor, A Hitchcock, CN Hunter… - … et Biophysica Acta (BBA …, 2021 - Elsevier
Cytochrome b 6 f (cytb 6 f) lies at the heart of the light-dependent reactions of oxygenic
photosynthesis, where it serves as a link between photosystem II (PSII) and photosystem I …

Architecture of human mitochondrial respiratory megacomplex I2III2IV2

R Guo, S Zong, M Wu, J Gu, M Yang - Cell, 2017 - cell.com
The respiratory megacomplex represents the highest-order assembly of respiratory chain
complexes, and it allows mitochondria to respond to energy-requiring conditions. To …

Structures of Tetrahymena's respiratory chain reveal the diversity of eukaryotic core metabolism

L Zhou, M Maldonado, A Padavannil, F Guo, JA Letts - Science, 2022 - science.org
Respiration is a core biological energy–converting process whose last steps are carried out
by a chain of multisubunit complexes in the inner mitochondrial membrane. To probe the …

The architecture of the mammalian respirasome

J Gu, M Wu, R Guo, K Yan, J Lei, N Gao, M Yang - Nature, 2016 - nature.com
The respiratory chain complexes I, III and IV (CI, CIII and CIV) are present in the bacterial
membrane or the inner mitochondrial membrane and have a role of transferring electrons …

Multifunctional Cytochrome c: Learning New Tricks from an Old Dog

D Alvarez-Paggi, L Hannibal, MA Castro… - Chemical …, 2017 - ACS Publications
Cytochrome c (cyt c) is a small soluble heme protein characterized by a relatively flexible
structure, particularly in the ferric form, such that it is able to sample a broad conformational …

Catalytic Reactions and Energy Conservation in the Cytochrome bc1 and b6f Complexes of Energy-Transducing Membranes

M Sarewicz, S Pintscher, R Pietras, A Borek… - Chemical …, 2021 - ACS Publications
This review focuses on key components of respiratory and photosynthetic energy-
transduction systems: the cytochrome bc 1 and b 6 f (Cyt bc 1/b 6 f) membranous …

[HTML][HTML] Superoxide generation by complex III: from mechanistic rationales to functional consequences

L Bleier, S Dröse - Biochimica et Biophysica Acta (BBA)-Bioenergetics, 2013 - Elsevier
Apart from complex I (NADH: ubiquinone oxidoreductase) the mitochondrial cytochrome bc
1 complex (complex III; ubiquinol: cytochrome c oxidoreductase) has been identified as the …

Cytochrome c phosphorylation: Control of mitochondrial electron transport chain flux and apoptosis

HA Kalpage, J Wan, PT Morse, MP Zurek… - The international journal …, 2020 - Elsevier
Cytochrome c (Cytc) 1 is a cellular life and death decision molecule that regulates cellular
energy supply and apoptosis through tissue specific post-translational modifications. Cytc is …

Arrangement of electron transport chain components in bovine mitochondrial supercomplex I1III2IV1

T Althoff, DJ Mills, JL Popot, W Kühlbrandt - The EMBO journal, 2011 - embopress.org
The respiratory chain in the inner mitochondrial membrane contains three large multi‐
enzyme complexes that together establish the proton gradient for ATP synthesis, and …