Diversity and dynamism of IgA− microbiota interactions
IgA mediates microbial homeostasis at the intestinal mucosa. Within the gut, IgA acts in a
context-dependent manner to both prevent and promote bacterial colonization and to …
context-dependent manner to both prevent and promote bacterial colonization and to …
Bioinformatic and statistical analysis of adaptive immune repertoires
High-throughput sequencing (HTS) of immune repertoires has enabled the quantitative
analysis of adaptive immune responses and offers the potential to revolutionize research in …
analysis of adaptive immune responses and offers the potential to revolutionize research in …
An antibody from single human VH-rearranging mouse neutralizes all SARS-CoV-2 variants through BA.5 by inhibiting membrane fusion
SARS-CoV-2 Omicron subvariants have generated a worldwide health crisis due to
resistance to most approved SARS-CoV-2 neutralizing antibodies and evasion of …
resistance to most approved SARS-CoV-2 neutralizing antibodies and evasion of …
Atlas of breast cancer infiltrated B-lymphocytes revealed by paired single-cell RNA-sequencing and antigen receptor profiling
To gain mechanistic insights into the functions and developmental dynamics of tumor-
infiltrated immune cells, especially B-lymphocytes, here we combine single-cell RNA …
infiltrated immune cells, especially B-lymphocytes, here we combine single-cell RNA …
In-depth determination and analysis of the human paired heavy-and light-chain antibody repertoire
BJ DeKosky, T Kojima, A Rodin, W Charab… - Nature medicine, 2015 - nature.com
High-throughput immune repertoire sequencing has emerged as a critical step in the
understanding of adaptive responses following infection or vaccination or in autoimmunity …
understanding of adaptive responses following infection or vaccination or in autoimmunity …
Association of the autoimmune disease scleroderma with an immunologic response to cancer
CG Joseph, E Darrah, AA Shah, AD Skora… - Science, 2014 - science.org
Autoimmune diseases are thought to be initiated by exposures to foreign antigens that cross-
react with endogenous molecules. Scleroderma is an autoimmune connective tissue …
react with endogenous molecules. Scleroderma is an autoimmune connective tissue …
Comprehensive serological profiling of human populations using a synthetic human virome
Introduction The collection of viruses found to infect humans can have profound effects on
human health. In addition to directly causing acute or chronic illness, viral infection can alter …
human health. In addition to directly causing acute or chronic illness, viral infection can alter …
A framework for highly multiplexed dextramer mapping and prediction of T cell receptor sequences to antigen specificity
T cell receptor (TCR) antigen–specific recognition is essential for the adaptive immune
system. However, building a TCR-antigen interaction map has been challenging due to the …
system. However, building a TCR-antigen interaction map has been challenging due to the …
Large-scale sequence and structural comparisons of human naive and antigen-experienced antibody repertoires
Elucidating how antigen exposure and selection shape the human antibody repertoire is
fundamental to our understanding of B-cell immunity. We sequenced the paired heavy-and …
fundamental to our understanding of B-cell immunity. We sequenced the paired heavy-and …
Systems analysis reveals high genetic and antigen-driven predetermination of antibody repertoires throughout B cell development
Antibody repertoire diversity and plasticity is crucial for broad protective immunity.
Repertoires change in size and diversity across multiple B cell developmental stages and in …
Repertoires change in size and diversity across multiple B cell developmental stages and in …