Current strategies to enhance delivery of drugs across the blood–brain barrier

RI Teleanu, MD Preda, AG Niculescu, O Vladâcenco… - Pharmaceutics, 2022 - mdpi.com
The blood–brain barrier (BBB) has shown to be a significant obstacle to brain medication
delivery. The BBB in a healthy brain is a diffusion barrier that prevents most substances from …

Recent advances in microscale electroporation

SE Choi, H Khoo, SC Hur - Chemical reviews, 2022 - ACS Publications
Electroporation (EP) is a commonly used strategy to increase cell permeability for
intracellular cargo delivery or irreversible cell membrane disruption using electric fields. In …

An atlas of nano-enabled neural interfaces

H Acarón Ledesma, X Li, JL Carvalho-de-Souza… - Nature …, 2019 - nature.com
Advances in microscopy and molecular strategies have allowed researchers to gain insight
into the intricate organization of the mammalian brain and the roles that neurons play in …

Advances in microfluidic in vitro systems for neurological disease modeling

PM Holloway, S Willaime‐Morawek… - Journal of …, 2021 - Wiley Online Library
Neurological disorders are the leading cause of disability and the second largest cause of
death worldwide. Despite significant research efforts, neurology remains one of the most …

Advances in microphysiological blood-brain barrier (BBB) models towards drug delivery

CS Lee, KW Leong - Current opinion in biotechnology, 2020 - Elsevier
Highlights•Various approaches exist to recreate 2D and 3D structures of the
BBB.•Quantitative barrier functions in some BBB-chips are comparable to in vivo …

Electro-responsive hydrogel-based microfluidic actuator platform for photothermal therapy

JH Ha, HH Shin, HW Choi, JH Lim, SJ Mo, CD Ahrberg… - Lab on a Chip, 2020 - pubs.rsc.org
Electrical stimuli play an important role in regulating the delivery of plasmonic nanomaterials
with cancer targeting peptides. Here, we developed an electro-responsive hydrogel-based …

Recent progress in microfluidic models of the blood-brain barrier

L Jiang, S Li, J Zheng, Y Li, H Huang - Micromachines, 2019 - mdpi.com
The blood-brain barrier (BBB) is a critical physical and chemical barrier that maintains brain
homeostasis. Researchers in academia and industry are highly motivated to develop …

Electrotherapies for glioblastoma

EPW Jenkins, A Finch, M Gerigk, IF Triantis… - Advanced …, 2021 - Wiley Online Library
Abstract Non‐thermal, intermediate frequency (100–500 kHz) electrotherapies present a
unique therapeutic strategy to treat malignant neoplasms. Here, pulsed electric fields (PEFs) …

Comprehensive development in organ-on-a-chip technology

X Joseph, V Akhil, A Arathi, PV Mohanan - Journal of Pharmaceutical …, 2022 - Elsevier
The expeditious advancement in the organ on chip technology provided a phase change to
the conventional in vitro tests used to evaluate absorption, distribution, metabolism …

Breaking barriers: exploring mechanisms behind opening the blood–brain barrier

MEM Stamp, M Halwes, D Nisbet, DJ Collins - Fluids and Barriers of the …, 2023 - Springer
The blood–brain barrier (BBB) is a selectively permeable membrane that separates the
bloodstream from the brain. While useful for protecting neural tissue from harmful …