Glioblastoma is an aggressive and heterogeneous tumor in which glioblastoma stem cells
(GSCs) are at the apex of an entropic hierarchy and impart devastating therapy resistance …

Hypoxia and inflammation are frequently co-incidental features of the tissue
microenvironment in a wide range of inflammatory diseases. While the impact of hypoxia on …

Objective: Neutrophil extracellular traps (NETs) produced by tumor-infiltrating neutrophils
(TINs) are associated with poor prognosis in patients with several types of cancer. However …

Lung cancer is the leading cause of cancer mortality worldwide, and at only 18%, it has one
of the lowest 5-year survival rates of all malignancies. With its highly complex mutational …

P2X7 is a transmembrane receptor expressed in multiple cell types including neurons,
dendritic cells, macrophages, monocytes, B and T cells where it can drive a wide range of …

The NF-κB transcription factor pathway is a crucial regulator of inflammation and immune
responses. Additionally, aberrant NF-κB signaling has been identified in many types of …

Despite decades of intense research, the complex biology of glioblastoma (GBM) is not
completely understood. Progression-free survival and overall survival have remained …

The innate immune system comprises a cellular and a humoral arm. Humoral pattern
recognition molecules include complement components, collectins, ficolins, and pentraxins …

Abstract Pentraxin-3 (PTX3) belongs to the pentraxine family, innate immune regulators
involved in angiogenesis, proliferation and immune escape in cancer. Here, we evaluated …

Activation of nuclear factor κB (NF-κB) induces mesenchymal (MES) transdifferentiation and
radioresistance in glioma stem cells (GSCs), but molecular mechanisms for NF-κB activation …