Genomic and transcriptional heterogeneity is prevalent among the most common and
aggressive primary brain tumors in children and adults. Over the past 20 years, advances in …

Background Previous studies have traditionally attributed the initiation of cancer cells to
genetic mutations, considering them as the fundamental drivers of carcinogenesis. However …

Simple Summary ATRX is one of the most frequently mutated tumor suppressor genes in
human cancers. ATRX protein is a chromatin remodeler and transcriptional regulator that is …

Despite its growing use in cancer treatment, immunotherapy has been virtually ineffective in
clinical trials for gliomas. The inherently cold tumor immune microenvironment (TIME) in …

The comprehensive dissection of the intratumoral ecosystem of human gliomas using single-
cell and spatial transcriptomic approaches advances our understanding of the mechanisms …

In recent years, the classification of adult-type diffuse gliomas has undergone a revolution,
wherein specific molecular features now represent defining diagnostic criteria of IDH-wild …

Background Glioblastoma (GBM) is one of the most common malignant brain tumors in
adults and is characterized by high aggressiveness and rapid progression, poor treatment …

Astrocytes are the most plentiful cell type in the central nervous system (CNS) and perform
complicated functions in health and disease. It is obvious that different astrocyte …

Background Roughly 50% of adult gliomas harbor isocitrate dehydrogenase (IDH)
mutations. According to the 2021 WHO classification guideline, these gliomas are …

Simple Summary We review the role of chromatin and epigenetic dysregulation in therapy
resistance in glioblastoma. We discuss how epigenetic and genetic forces may cooperate to …