Early-stage organ transplant rejection can be difficult to detect. Percutaneous biopsies occur
infrequently and are risky, and measuring biomarker levels in blood can lead to false …

Preclinical animal studies are mandatory before new treatments can be tested in clinical
trials. However, their use in developing new therapies for sepsis has been controversial …

Neonatal shock and necrotizing enterocolitis (NEC) are leading causes of morbidity and
mortality in premature infants. NEC is a life-threatening gastrointestinal illness, the precise …

Introduction Sepsis is characterized by a dysregulated host immune response to infection,
leading to organ dysfunction and a high risk of death. The cecal ligation and puncture (CLP) …

Background Sepsis is the overwhelming host response to infection leading to shock and
multiple organ dysfunction. Cardiovascular complications greatly increase sepsis …

Sepsis is the overwhelming systemic immune response to infection, which can result in
multiple organ dysfunction and septic shock. Myocardial dysfunction during sepsis is …

Skeletal muscles secrete a wide variety of immunologically active cytokines, but the
functional significance of this response to in vivo innate immunity is not understood. We …

New Findings What is the central question of this study? Exertional heat stroke is
accompanied by a marked inflammatory response. In this study, we explored the time course …

Abstract Interleukin-6 (IL-6) is a major cytokine released by skeletal muscle. Although IL-6
plays complex but well-known roles in host defense, the specific contribution of skeletal …

BACKGROUND: Accumulating evidence implicates the activation of G-protein–coupled
PARs (protease-activated receptors) by coagulation proteases in the regulation of innate …