mTOR is an evolutionarily conserved serine/threonine kinase that plays a central role in
integrating environmental cues in the form of growth factors, amino acids, and energy. In the …

The potent immunosuppressive action of rapamycin is commonly ascribed to inhibition of
growth factor-induced T cell proliferation. However, it is now evident that the …

Both the programmed death (PD) 1–PD-ligand (PD-L) pathway and regulatory T (T reg) cells
are instrumental to the maintenance of peripheral tolerance. We demonstrate that PD-L1 has …

Acute graft-versus-host disease (aGVHD) is associated with high risk of morbidity and
mortality and is a common complication after double umbilical cord blood (UCB) …

Regulatory T (TReg) cells constitute a unique T-cell lineage that has a crucial role in
immunological tolerance. Several years ago, forkhead box P3 (FOXP3) was identified as the …

Background Myeloablative allogeneic hematopoietic stem-cell transplantation is curative in
children with sickle cell disease, but in adults the procedure is unduly toxic. Graft rejection …

Mammalian/mechanistic target of rapamycin (mTOR) is emerging as an important integrator
of environmental cues critical for the regulation of T cell activation, differentiation, and …

Based on their ability to control T-cell homeostasis, Foxp3+ CD4+ CD25+ regulatory T cells
(Tregs) are being considered for treatment of autoimmune disorders and acute graft-versus …

Reciprocal differentiation of immunosuppressive CD4+ CD25+ FoxP3+ T regulatory cells
(Tregs) and proinflammatory IL-17-producing cells (Th17) from naïve CD4 cells is contingent …

The autoimmune polyglandular syndromes—a group of syndromes comprising a
combination of endocrine and nonendocrine autoimmune diseases—differ in their …