The neuroscience of drug reward and addiction

ND Volkow, M Michaelides, R Baler - Physiological reviews, 2019 - journals.physiology.org
Drug consumption is driven by a drug's pharmacological effects, which are experienced as
rewarding, and is influenced by genetic, developmental, and psychosocial factors that …

The why behind the high: determinants of neurocognition during acute cannabis exposure

JG Ramaekers, NL Mason, L Kloft… - Nature Reviews …, 2021 - nature.com
Acute cannabis intoxication may induce neurocognitive impairment and is a possible cause
of human error, injury and psychological distress. One of the major concerns raised about …

A randomised controlled trial of vaporised Δ9-tetrahydrocannabinol and cannabidiol alone and in combination in frequent and infrequent cannabis users: acute …

N Solowij, S Broyd, L Greenwood, H van Hell… - European archives of …, 2019 - Springer
Access to cannabis and cannabinoid products is increasing worldwide for recreational and
medicinal use. Two primary compounds within cannabis plant matter, Δ 9 …

Role of the endocannabinoid system in drug addiction

J Manzanares, D Cabañero, N Puente… - Biochemical …, 2018 - Elsevier
Drug addiction is a chronic relapsing disorder that produces a dramatic global health burden
worldwide. Not effective treatment of drug addiction is currently available probably due to the …

Blunted highs: pharmacodynamic and behavioral models of cannabis tolerance

JG Ramaekers, NL Mason, EL Theunissen - European …, 2020 - Elsevier
Acute exposure to cannabis comes with neurocognitive impairment, leading to increased
risk of human error and injury. Evidence however indicates that such acute effects are less …

Terpenoids Commonly Found in Cannabis sativa Do Not Modulate the Actions of Phytocannabinoids or Endocannabinoids on TRPA1 and TRPV1 Channels

M Heblinski, M Santiago, C Fletcher… - Cannabis and …, 2020 - liebertpub.com
Introduction: Cannabis sativa produces hundreds of bioactive compounds, including
cannabinoids and terpenoids. It has been proposed that cannabinoids act in synergy with …

Interactions between cannabidiol and Δ9‐tetrahydrocannabinol in modulating seizure susceptibility and survival in a mouse model of Dravet syndrome

LL Anderson, IK Low, IS McGregor… - British Journal of …, 2020 - Wiley Online Library
Background and Purpose Extracts from the cannabis plant can dramatically improve the
health of children suffering from refractory epilepsies such as Dravet syndrome. These …

Crosstalk between the endocannabinoid and mid-brain dopaminergic systems: Implication in dopamine dysregulation

BG Kibret, A Canseco-Alba, ES Onaivi… - Frontiers in Behavioral …, 2023 - frontiersin.org
Endocannabinoids (eCBs) and the expanded endocannabinoid system (ECS)-
“endocannabinoidome”, consists of the endogenous ligands, eCBs, their canonical and non …

Adolescent Δ9-tetrahydrocannabinol exposure and astrocyte-specific genetic vulnerability converge on nuclear factor-κB–cyclooxygenase-2 signaling to impair …

Y Jouroukhin, X Zhu, AV Shevelkin, Y Hasegawa… - Biological …, 2019 - Elsevier
Background Although several studies have linked adolescent cannabis use to long-term
cognitive dysfunction, there are negative reports as well. The fact that not all users develop …

Cerebellar alterations in cannabis users: A systematic review

C Blithikioti, L Miquel, A Batalla, B Rubio… - Addiction …, 2019 - Wiley Online Library
Cannabis is the most used illicit substance in the world. As many countries are moving
towards decriminalization, it is crucial to determine whether and how cannabis use affects …