The reactive oxygen species (ROS)-producing enzyme NADPH oxidase (NOX) was first
identified in the membrane of phagocytic cells. For many years, its only known role was in …

Hydrogen peroxide emerged as major redox metabolite operative in redox sensing,
signaling and redox regulation. Generation, transport and capture of H 2 O 2 in biological …

Hydrogen peroxide (H2O2) is an important metabolite involved in most of the redox
metabolism reactions and processes of the cells. H2O2 is recognized as one of the main …

Aging is a complex phenomenon and its impact is becoming more relevant due to the rising
life expectancy and because aging itself is the basis for the development of age-related …

Zinc and cellular oxidants such as reactive oxygen species (ROS) each participate in a
multitude of physiological functions. There is considerable overlap between the affected …

Abstract The terms 'antioxidant','oxidative stress' and 'oxidative damage'are widely used but
rarely defined. This brief review attempts to define them and to examine the ways in which …

Reactive oxygen species (ROS) and reactive nitrogen species (RNS) play important roles in
regulation of cell survival. In general, moderate levels of ROS/RNS may function as signals …

It is well established that oxidative stress is an important cause of cell damage associated
with the initiation and progression of many diseases. Consequently, all air-living organisms …

The reactive oxygen species that are generated by mitochondrial respiration, including
hydrogen peroxide (H2O2), are potent inducers of oxidative damage and mediators of …

Oxidative stress is an increase in the reduction potential or a large decrease in the reducing
capacity of the cellular redox couples. A particularly destructive aspect of oxidative stress is …