This Review explores the dynamic behavior of water within nanopores and biological
channels in lipid bilayer membranes. We focus on molecular simulation studies, alongside …

Biological ion channels are nanoscale transmembrane pores. When water and ions are
enclosed within the narrow confines of a sub-nanometer hydrophobic pore, they exhibit …

Bacteria represent one of the most evolutionarily successful groups of organisms to inhabit
Earth. Their world is awash with mechanical cues, probably the most ancient form of which …

Transport of ions through pores in membranes is a process of fundamental importance to
cell biology. In living organisms, such transport is facilitated by ion channels that utilize the …

Prokaryotic mechanosensitive (MS) channels open by sensing the physical state of the
membrane. As such, lipid-protein interactions represent the defining molecular process …

Nanofluidics, the field interested in flows at the smallest scales, has grown at a fast pace,
reaching an ever finer control of fluidic and ionic transport at the molecular level. Until now …

Cells perceive force through a variety of molecular sensors, of which the mechanosensitive
ion channels are the most efficient and act the fastest. These channels apparently evolved to …

Recent X-ray crystal structures of the two-pore domain (K2P) family of potassium channels
have revealed a unique structural architecture at the point where the cytoplasmic bundle …

Piezo ion channels have been found to be essential for mechanical responses in cells.
These channels were first shown to exist in Neuro2A cells, and the gene was identified by …

Quaternary ammonium blockers were previously shown to bind in the pore to block both
open and closed conformations of large-conductance calcium-activated potassium (BK and …