[HTML][HTML] Antibiotics in the clinical pipeline as of December 2022

MS Butler, IR Henderson, RJ Capon… - The Journal of …, 2023 - nature.com
The need for new antibacterial drugs to treat the increasing global prevalence of drug-
resistant bacterial infections has clearly attracted global attention, with a range of existing …

Chemically modified and conjugated antimicrobial peptides against superbugs

W Li, F Separovic, NM O'Brien-Simpson… - Chemical Society …, 2021 - pubs.rsc.org
Antimicrobial resistance (AMR) is one of the greatest threats to human health that, by 2050,
will lead to more deaths from bacterial infections than cancer. New antimicrobial agents …

[图书][B] 2019 antibacterial agents in clinical development: an analysis of the antibacterial clinical development pipeline

World Health Organization - 2020 - books.google.com
Some rights reserved. This work is available under the Creative Commons Attribution-
NonCommercial-ShareAlike 3.0 IGO licence (CC BY-NC-SA 3.0 IGO; https …

Analysis of the clinical pipeline of treatments for drug-resistant bacterial infections: despite progress, more action is needed

MS Butler, V Gigante, H Sati, S Paulin… - Antimicrobial agents …, 2022 - Am Soc Microbiol
There is an urgent global need for new strategies and drugs to control and treat multidrug-
resistant bacterial infections. In 2017, the World Health Organization (WHO) released a list of …

[HTML][HTML] Towards the sustainable discovery and development of new antibiotics

M Miethke, M Pieroni, T Weber, M Brönstrup… - Nature Reviews …, 2021 - nature.com
An ever-increasing demand for novel antimicrobials to treat life-threatening infections
caused by the global spread of multidrug-resistant bacterial pathogens stands in stark …

The global preclinical antibacterial pipeline

U Theuretzbacher, K Outterson, A Engel… - Nature Reviews …, 2020 - nature.com
Antibacterial resistance is a great concern and requires global action. A critical question is
whether enough new antibacterial drugs are being discovered and developed. A review of …

Antibiotic resistance in the patient with cancer: Escalating challenges and paths forward

AK Nanayakkara, HW Boucher… - CA: a cancer journal …, 2021 - Wiley Online Library
Infection is the second leading cause of death in patients with cancer. Loss of efficacy in
antibiotics due to antibiotic resistance in bacteria is an urgent threat against the continuing …

[HTML][HTML] 2021 antibacterial agents in clinical and preclinical development: an overview and analysis

World Health Organization - 2022 - books.google.com
Page 1 2021 ANTIBACTERIAL AGENTS IN CLINICAL AND PRECLINICAL DEVELOPMENT:
an overview and analysis World Health Organization Page 2 A PRE Page 3 2021 …

Critical analysis of antibacterial agents in clinical development

U Theuretzbacher, K Bush, S Harbarth… - Nature Reviews …, 2020 - nature.com
The antibacterial agents currently in clinical development are predominantly derivatives of
well-established antibiotic classes and were selected to address the class-specific …

[HTML][HTML] Safer plant-based nanoparticles for combating antibiotic resistance in bacteria: A comprehensive review on its potential applications, recent advances, and …

U Anand, M Carpena, M Kowalska-Góralska… - Science of The Total …, 2022 - Elsevier
Background Antibiotic resistance is one of the current threats to human health, forcing the
use of drugs that are more noxious, costlier, and with low efficiency. There are several …