Abstract N 7-methylguanosine (m7G), one of the most prevalent RNA modifications, has
recently attracted significant attention. The m7G modification actively participates in …

The tumour microenvironment (TME) imposes a major obstacle to infiltrating T-lymphocytes
and suppresses their function. Several immune checkpoint proteins that interfere with …

In the later-line setting or for patients with PD-L1-negative tumors, immunotherapy-based
regimens remain ineffective against advanced triple-negative breast cancer (TNBC). In this …

This review highlights new findings that have deepened our understanding of the
mechanisms of leukemogenesis, therapy and resistance in acute promyelocytic leukemia …

The ectonucleotidases CD39 and CD73 are cell surface enzymes that catabolize the
breakdown of extracellular ATP into adenosine. As such, they constitute critical components …

Aberrant overexpression or activation of EGFR drives the development of non-small cell
lung cancer (NSCLC) and acquired resistance to EGFR tyrosine kinase inhibitors (TKIs) by …

Uncontrolled inflammatory response arising from the tumor microenvironment (TME)
significantly contributes to cancer progression, prompting an investigation and careful …

Protein post-translational modification (PTM) is a regulatory mechanism for protein activity
modulation, localization, expression, and interactions with other cellular molecules. It …

The tripartite motif (TRIM) family is defined by the presence of a Really Interesting New Gene
(RING) domain, one or two B-box motifs and a coiled-coil region. TRIM proteins play key …

Photothermal therapy has shown great promise for cancer treatment and second near-
infrared (NIR-II)-absorbing particles could further improve its precision and applicability due …