As a central hub for cellular metabolism and intracellular signaling, the mitochondrion is a
pivotal organelle, dysfunction of which has been linked to several human diseases including …

Mitochondria perform crucial functions in cellular metabolism, protein and lipid biogenesis,
quality control, and signaling. The systematic analysis of protein complexes and interaction …

Mitochondria have crucial roles in cellular energetics, metabolism, signalling and quality
control,,–. They contain around 1,000 different proteins that often assemble into complexes …

Mitochondria import 1000–1300 different precursor proteins from the cytosol. The main
mitochondrial entry gate is formed by the translocase of the outer membrane (TOM …

The abundance of each cellular protein is dynamically adjusted to the prevailing metabolic
and stress conditions by modulation of their synthesis and degradation rates. The …

Protein homeostasis, or proteostasis, is crucial for the functioning of a cell, as proteins that
are mislocalized, present in excessive amounts, or aberrant due to misfolding or other type …

Dysregulation of factors in nucleocytoplasmic transport is closely linked to neural
developmental diseases. Mutation in Hikeshi, encoding a nonconventional nuclear import …

The diverse functions of proteins depend on their proper three-dimensional folding and
assembly. Misfolded cellular proteins can potentially harm cells by forming aggregates in …

The Hsp70 chaperone system is a central component of cellular protein quality control
(PQC) by acting in a multitude of protein folding processes ranging from the folding of newly …

Despite the devastating clinical outcome of the neurodegenerative disease, amyotrophic
lateral sclerosis (ALS), its etiology remains mysterious. Approximately 90% of ALS is …