The adaptive transition of glioblastoma stem cells and its implications on treatments
Glioblastoma is the most malignant tumor occurring in the human central nervous system
with overall median survival time< 14.6 months. Current treatments such as chemotherapy …
with overall median survival time< 14.6 months. Current treatments such as chemotherapy …
The endoplasmic reticulum stress/unfolded protein response in gliomagenesis, tumor progression and as a therapeutic target in glioblastoma
NMP Fajardo, C Meijer, FAE Kruyt - Biochemical pharmacology, 2016 - Elsevier
Endoplasmic reticulum (ER) stress disrupts among others protein homeostasis in cells
leading to the activation of the unfolded protein response (UPR) that is crucial for restoring …
leading to the activation of the unfolded protein response (UPR) that is crucial for restoring …
Strategies of temozolomide in future glioblastoma treatment
CY Lee - OncoTargets and therapy, 2017 - Taylor & Francis
Glioblastoma multiforme (GBM) may be one of the most challenging brain tumors to treat, as
patients generally do not live more than 2 years. This review aimed to give a timely review of …
patients generally do not live more than 2 years. This review aimed to give a timely review of …
The DNA double-strand break repair in glioma: Molecular players and therapeutic strategies
S Maksoud - Molecular Neurobiology, 2022 - Springer
Gliomas are the most frequent type of tumor in the central nervous system, which exhibit
properties that make their treatment difficult, such as cellular infiltration, heterogeneity, and …
properties that make their treatment difficult, such as cellular infiltration, heterogeneity, and …
Intranasal perillyl alcohol for glioma therapy: molecular mechanisms and clinical development
TC Chen, CO Da Fonseca, AH Schönthal - International journal of …, 2018 - mdpi.com
Intracranial malignancies, such as primary brain cancers and brain-localized metastases
derived from peripheral cancers, are particularly difficult to treat with therapeutic agents …
derived from peripheral cancers, are particularly difficult to treat with therapeutic agents …
Current applications and future prospects of nanomaterials in tumor therapy
Y Huang, CQ Fan, H Dong, SM Wang… - International journal …, 2017 - Taylor & Francis
Tumors are one of the most serious human diseases and cause numerous global deaths per
year. In spite of many strategies applied in tumor therapy, such as radiation therapy …
year. In spite of many strategies applied in tumor therapy, such as radiation therapy …
Encapsulation of temozolomide in a calixarene nanocapsule improves its stability and enhances its therapeutic efficacy against glioblastoma
A Renziehausen, AD Tsiailanis, R Perryman… - Molecular cancer …, 2019 - AACR
The alkylating agent temozolomide (TMZ) is the first-line chemotherapeutic for glioblastoma
(GBM), a common and aggressive primary brain tumor in adults. However, its poor stability …
(GBM), a common and aggressive primary brain tumor in adults. However, its poor stability …
The monoterpenoid perillyl alcohol: Anticancer agent and medium to overcome biological barriers
TC Chen, CO da Fonseca, D Levin, AH Schönthal - Pharmaceutics, 2021 - mdpi.com
Perillyl alcohol (POH) is a naturally occurring monoterpenoid related to limonene that is
present in the essential oils of various plants. It has diverse applications and can be found in …
present in the essential oils of various plants. It has diverse applications and can be found in …
Neo212, a perillyl alcohol-temozolomide conjugate, triggers macrophage differentiation of acute myeloid leukemia cells and blocks their tumorigenicity
TC Chen, RO Minea, S Swenson, Z Yang, TZ Thein… - Cancers, 2022 - mdpi.com
Simple Summary Acute myeloid leukemia (AML) is a cancer of the blood and bone marrow,
where cancer cells are unable to complete the maturation process towards white blood cells …
where cancer cells are unable to complete the maturation process towards white blood cells …
NEO212, a conjugate of temozolomide and perillyl alcohol, blocks the endothelial-to-mesenchymal transition in tumor-associated brain endothelial cells in …
NI Marín-Ramos, N Jhaveri, TZ Thein, RA Fayngor… - Cancer letters, 2019 - Elsevier
As the endothelial-to-mesenchymal transition (EndMT) supports the pro-angiogenic and
invasive characteristics of glioblastoma multiforme (GBM), blocking this process would be a …
invasive characteristics of glioblastoma multiforme (GBM), blocking this process would be a …