Osteoarthritis (OA) is the most common joint disease worldwide and a leading cause of
disability. Characterized by degradation of articular cartilage, synovial inflammation, and …

Segmentation of the paraxial mesoderm is a major event of vertebrate development that
establishes the metameric patterning of the body axis. This process involves the periodic …

The emergence of the three germ layers and the lineage-specific precursor cells
orchestrating organogenesis represent fundamental milestones during early embryonic …

Background Cytosine DNA methylation is widely described as a transcriptional repressive
mark with the capacity to silence promoters. Epigenome engineering techniques enable …

Parenchymal astrocytes have emerged as a potential reservoir for new neurons in non-
neurogenic brain regions. It is currently unclear how astrocyte neurogenesis is controlled …

Activation of Notch signaling induces the expression of transcriptional repressor genes such
as Hes1, leading to repression of proneural gene expression and maintenance of neural …

Notch 1 to 4 receptors are important determinants of cell fate and function, and Notch
signaling plays an important role in skeletal development and bone remodeling. After direct …

The pancreas is an essential organ for proper nutrient metabolism and has both endocrine
and exocrine function. In the past two decades, knowledge of how the pancreas develops …

Correct development of the human placenta and its differentiated epithelial cells, syncytial
trophoblasts (STBs) and extravillous trophoblasts (EVTs), is crucial for a successful …

Expression of the Notch effector gene Hes1 is required for maintenance of neural
progenitors in the embryonic brain, but persistent and high levels of Hes1 expression inhibit …