Biomechanics of collective cell migration in cancer progression: experimental and computational methods

CP Spatarelu, H Zhang, DT Nguyen… - ACS biomaterials …, 2019 - ACS Publications
Cell migration is essential for regulating many biological processes in physiological or
pathological conditions, including embryonic development and cancer invasion. In vitro and …

Probing Multicellular Tissue Fusion of Cocultured Spheroids—A 3D‐Bioassembly Model

GCJ Lindberg, X Cui, M Durham… - Advanced …, 2021 - Wiley Online Library
While decades of research have enriched the knowledge of how to grow cells into mature
tissues, little is yet known about the next phase: fusing of these engineered tissues into …

Alteration in cartilage matrix stiffness as an indicator and modulator of osteoarthritis

J Song, X Zeng, C Li, H Yin, S Mao, D Ren - Bioscience Reports, 2024 - portlandpress.com
Osteoarthritis (OA) is characterized by cartilage degeneration and destruction, leading to
joint ankylosis and disability. The major challenge in diagnosing OA at early stage is not …

Chloride channel and inflammation-mediated pathogenesis of osteoarthritis

Z Lin, Z Deng, J Liu, Z Lin, S Chen… - Journal of Inflammation …, 2022 - Taylor & Francis
Articular cartilage allows the human body to buffer and absorb stress during normal
exercise. It is mainly composed of cartilage cells and the extracellular matrix and is …

Investigation of cell-substrate adhesion properties of living chondrocyte by measuring adhesive shear force and detachment using AFM and inverse FEA

TD Nguyen, YT Gu - Scientific reports, 2016 - nature.com
It is well-known that cell adhesion is important in many biological processes such as cell
migration and proliferation. A better understanding of the cell adhesion process will shed …

Effect of substrate stiffness on mechanical coupling and force propagation at the infarct boundary

DT Nguyen, N Nagarajan, P Zorlutuna - Biophysical journal, 2018 - cell.com
Heterogeneous intercellular coupling plays a significant role in mechanical and electrical
signal transmission in the heart. Although many studies have investigated the electrical …

Cellular volume regulation and substrate stiffness modulate the detachment dynamics of adherent cells

Y Yang, H Jiang - Journal of the Mechanics and Physics of Solids, 2018 - Elsevier
Quantitative characterizations of cell detachment are vital for understanding the fundamental
mechanisms of cell adhesion. Experiments have found that cell detachment shows strong …

Cell mechanics: Are poroviscoelastic parameters reliable?

B Klahr, OT Pinto, TA Carniel, EA Fancello - Mechanics Research …, 2021 - Elsevier
Motivated by a literature survey on the mechanical characterization of single cells by
biphasic models, the present study seeks to answer if the large dispersion on the …

An open-source combined atomic force microscope and optical microscope for mechanobiology studies

D Delgado, S Desroches, G Kang, Y Aldabii, AR Harris - Heliyon, 2024 - cell.com
Abstract Atomic Force Microscopy (AFM) has become the gold standard tool for measuring
mechanical properties of biological samples including proteins, single cells and tissues …

[HTML][HTML] Poroelastic osmoregulation of living cell volume

MH Esteki, A Malandrino, AA Alemrajabi, GK Sheridan… - Iscience, 2021 - cell.com
Cells maintain their volume through fine intracellular osmolarity regulation. Osmotic
challenges drive fluid into or out of cells causing swelling or shrinkage, respectively. The …