Transient receptor potential vanilloid subtype 3 (TRPV3) is an ion channel with a sensory
function that is most abundantly expressed in keratinocytes and peripheral neurons. TRPV3 …

Pharmacomodulation of membrane channels is an essential topic in the study of
physiological conditions and disease status. Transient receptor potential (TRP) channels are …

Pain therapy has remained conceptually stagnant since the opioid crisis, which highlighted
the dangers of treating pain with opioids. An alternative addiction-free strategy to …

Transient receptor potential (TRP) channels are a large, eukaryotic ion channel superfamily
that control diverse physiological functions, and therefore are attractive drug targets,,,–. More …

The transient receptor potential channel TRPM7 is a master regulator of the organismal
balance of divalent cations that plays an essential role in embryonic development, immune …

Transient receptor potential (TRP) channel TRPV4 is a polymodal cellular sensor that
responds to moderate heat, cell swelling, shear stress, and small-molecule ligands. It is …

The calcium-selective oncochannel TRPV6 is an important driver of cell proliferation in
human cancers. Despite increasing interest of pharmacological research in developing …

Calcium-selective oncochannel TRPV6 is the major driver of cell proliferation in human
cancers. While significant effort has been invested in the development of synthetic TRPV6 …

The transient receptor potential vanilloid 2 (TRPV2) ion channel is a polymodal receptor
widely involved in many physiological and pathological processes. Despite many TRPV2 …

TRPV3 represents both temperature-and ligand-activated transient receptor potential (TRP)
channel. Physiologically relevant opening of TRPV3 channels by heat has been captured …