Mitochondrial dysfunction in schizophrenia: pathways, mechanisms and implications
Mitochondria play a critical role in regulating cellular functions including bioenergetics,
calcium homeostasis, redox signalling, and apoptotic cell death. Mitochondria are also …
calcium homeostasis, redox signalling, and apoptotic cell death. Mitochondria are also …
Pharmacogenetics of antipsychotic drug treatment: update and clinical implications
K Yoshida, DJ Müller - Complex Psychiatry, 2019 - karger.com
Numerous genetic variants have been shown to be associated with antipsychotic response
and adverse effects of schizophrenia treatment. However, the clinical application of these …
and adverse effects of schizophrenia treatment. However, the clinical application of these …
Clinical utility of combinatorial pharmacogenomic testing in depression: A Canadian patient-and rater-blinded, randomized, controlled trial
The pharmacological treatment of depression consists of stages of trial and error, with less
than 40% of patients achieving remission during first medication trial. However, in a large …
than 40% of patients achieving remission during first medication trial. However, in a large …
Expression-based drug screening of neural progenitor cells from individuals with schizophrenia
B Readhead, BJ Hartley, BJ Eastwood… - Nature …, 2018 - nature.com
A lack of biologically relevant screening models hinders the discovery of better treatments
for schizophrenia (SZ) and other neuropsychiatric disorders. Here we compare the …
for schizophrenia (SZ) and other neuropsychiatric disorders. Here we compare the …
The complex interaction of mitochondrial genetics and mitochondrial pathways in psychiatric disease
AB Cuperfain, ZL Zhang, JL Kennedy… - Complex …, 2018 - karger.com
While accounting for only 2% of the body's weight, the brain utilizes up to 20% of the body's
total energy. Not surprisingly, metabolic dysfunction and energy supply-and-demand …
total energy. Not surprisingly, metabolic dysfunction and energy supply-and-demand …
Antipsychotic induced weight gain: genetics, epigenetics, and biomarkers reviewed
TA Shams, DJ Müller - Current psychiatry reports, 2014 - Springer
Antipsychotic-induced weight gain (AIWG) is a prevalent side effect of antipsychotic
treatment, particularly with second generation antipsychotics, such as clozapine and …
treatment, particularly with second generation antipsychotics, such as clozapine and …
Catechol-O-methyltransferase Val158Met polymorphism and clinical response to antipsychotic treatment in schizophrenia and schizo-affective disorder patients: a …
Background: The catechol-O-methyltransferase (COMT) enzyme plays a crucial role in
dopamine degradation, and the COMT Val158Met polymorphism (rs4680) is associated with …
dopamine degradation, and the COMT Val158Met polymorphism (rs4680) is associated with …
New findings in pharmacogenetics of schizophrenia
The findings to date are promising and provide us a better understanding of the
development of side effects and response to antipsychotics. However, more comprehensive …
development of side effects and response to antipsychotics. However, more comprehensive …
Genome-wide association study on antipsychotic-induced weight gain in the CATIE sample
Antipsychotic-induced weight gain (AIWG) is a common side effect with a high genetic
contribution. We reanalyzed genome-wide association study (GWAS) data from the Clinical …
contribution. We reanalyzed genome-wide association study (GWAS) data from the Clinical …
Genome-Wide Association Study Suggested the PTPRD Polymorphisms Were Associated With Weight Gain Effects of Atypical Antipsychotic …
H Yu, L Wang, L Lv, C Ma, B Du, T Lu, C Jin… - Schizophrenia …, 2016 - academic.oup.com
Background: Antipsychotic-induced weight gain (AIWG) is a serious concern in therapy with
antipsychotic medications. To identify single nucleotide polymorphisms (SNPs) associated …
antipsychotic medications. To identify single nucleotide polymorphisms (SNPs) associated …