Cellular senescence, classically defined as stable cell cycle arrest, is implicated in biological
processes such as embryogenesis, wound healing and ageing. Senescent cells have a …

The quantification of the biological age of cells yields great promises for accelerating the
discovery of novel rejuvenation strategies. Here, we present MultiTIMER, the first multi …

Aging is associated with widespread physiological changes, including skeletal muscle
weakening, neuron system degeneration, hair loss, and skin wrinkling. Previous studies …

Aging is the major risk factor for cardiovascular disease, which is the leading cause of
mortality worldwide among aging populations. Cisd2 is a prolongevity gene that mediates …

Sepsis is the leading systemic inflammatory response syndrome in worldwide, yet relatively
little is known about the genes and signaling pathways involved in sepsis progression. The …

Objectives: The underlying molecular mechanisms of diabetic nephropathy have yet not
been investigated clearly. In this investigation, we aimed to identify key genes involved in …

Coronary artery disease (CAD) is the most common cardiovascular disorder and the leading
cause of heart-related deaths in world. Increasing molecular targets have been discovered …

Background. Decidualization of ectopic endometrium often leads to the extensive
proliferation of local tissue and is easily misdiagnosed as malignant tumors. The study is …

Cardiovascular diseases (CVDs) are the leading cause of disease burden and mortality in
the world, as well as a major cause of disability and health care costs. With the average …

Pathological alterations in cardiac tissue structure and functioning lead to cardiovascular
diseases, which are the leading cause of disease burden and mortality in the world. They …