Circadian timekeeping systems drive oscillatory gene expression to regulate essential
cellular and physiological processes. When the systems are perturbed, pathological …

Resetting the circadian clock leads to well being and increased life span, whereas clock
disruption is associated with aging and morbidity. Increased longevity and improved health …

Circadian disruption aggravates age-related decline and mortality. However, it remains
unclear whether circadian enhancement can retard aging in mammals. We previously …

Disruption of circadian rhythms leads to obesity and metabolic disorders. Timed restricted
feeding (RF) provides a time cue and resets the circadian clock, leading to better health. In …

Circadian rhythms are daily oscillations in physiology and behaviour that recur with a period
of 24h, and that are entrained by the daily photoperiod. The cycle of sunrise and sunset …

More than half of the elderly in today's society suffer from sleep disorders with detrimental
effects on brain function, behavior, and social life. A major contribution to the regulation of …

Normal physiological functions require a robust biological timer called the circadian clock.
When clocks are dysregulated, misaligned, or dampened, pathological consequences …

Background The cholinergic anti‐inflammatory pathway is proposed to be part of the so‐
called vago‐vagal 'inflammatory reflex'. The aim of this study is to provide neuro‐anatomical …

The circadian clock machinery orchestrates organism metabolism to ensure that
development, survival, and reproduction are attuned to diurnal environmental variations. For …

The mammalian circadian clock regulates a wide variety of physiological and behavioral
processes. In turn, its disruption is associated with sleep deficiency, metabolic syndrome …