[HTML][HTML] Desaturases and elongases involved in long-chain polyunsaturated fatty acid biosynthesis in aquatic animals: From genes to functions

Ó Monroig, AC Shu-Chien, N Kabeya, DR Tocher… - Progress in lipid …, 2022 - Elsevier
Marine ecosystems are rich in “omega-3” long-chain (C 20-24) polyunsaturated fatty acids
(LC-PUFA). Their production has been historically accepted to derive mostly from marine …

Long-chain polyunsaturated fatty acid biosynthesis in chordates: Insights into the evolution of Fads and Elovl gene repertoire

LFC Castro, DR Tocher, O Monroig - Progress in lipid research, 2016 - Elsevier
Long-chain polyunsaturated fatty acids (LC-PUFA) are major components of complex lipid
molecules and are also involved in numerous critical biological processes. Studies …

Regulation of long-chain polyunsaturated fatty acid biosynthesis in teleost fish

D Xie, C Chen, Y Dong, C You, S Wang… - Progress in Lipid …, 2021 - Elsevier
Abstract Omega-3 (n-3) long-chain polyunsaturated fatty acids (LC-PUFA, C 20-24),
including eicosapentaenoic acid (EPA, 20: 5n-3) and docosahexaenoic acid (DHA, 22: 6n …

[HTML][HTML] Vitamin E inadequacy in humans: causes and consequences

MG Traber - Advances in nutrition, 2014 - Elsevier
It is estimated that> 90% of Americans do not consume sufficient dietary vitamin E, as α-
tocopherol, to meet estimated average requirements. What are the adverse consequences …

Biosynthesis of polyunsaturated fatty acids in marine invertebrates: recent advances in molecular mechanisms

Ó Monroig, DR Tocher, JC Navarro - Marine drugs, 2013 - mdpi.com
Virtually all polyunsaturated fatty acids (PUFA) originate from primary producers but can be
modified by bioconversions as they pass up the food chain in a process termed trophic …

Desaturases and elongases involved in polyunsaturated fatty acid biosynthesis in aquatic invertebrates: a comprehensive review

Ó Monroig, N Kabeya - Fisheries Science, 2018 - Springer
Invertebrates represent a large proportion of the biomass in aquatic ecosystems, particularly
in the ocean. In recent years, invertebrates have been well-consolidated models in …

Novel cellular functions of very long chain-fatty acids: insight from ELOVL4 mutations

F Deák, RE Anderson, JL Fessler… - Frontiers in cellular …, 2019 - frontiersin.org
Elongation of Very Long chain fatty acids-4 (ELOVL4) protein is a member of the ELOVL
family of fatty acid elongases that is collectively responsible for catalyzing formation of long …

[HTML][HTML] Docosanoids and elovanoids from omega-3 fatty acids are pro-homeostatic modulators of inflammatory responses, cell damage and neuroprotection

NG Bazan - Molecular aspects of medicine, 2018 - Elsevier
The functional significance of the selective enrichment of the omega-3 essential fatty acid
docosahexaenoic acid (DHA; 22C and 6 double bonds) in cellular membrane phospholipids …

[HTML][HTML] Two alternative pathways for docosahexaenoic acid (DHA, 22: 6n-3) biosynthesis are widespread among teleost fish

A Oboh, N Kabeya, G Carmona-Antoñanzas… - Scientific reports, 2017 - nature.com
Docosahexaenoic acid (DHA) plays important physiological roles in vertebrates. Studies in
rats and rainbow trout confirmed that DHA biosynthesis proceeds through the so-called …

Understanding the roles of very-long-chain polyunsaturated fatty acids (VLC-PUFAs) in eye health

U Nwagbo, PS Bernstein - Nutrients, 2023 - mdpi.com
Lipids serve many roles in the neural system, from synaptic stabilization and signaling to
DNA regulation and neuroprotection. They also regulate inflammatory responses, maintain …