Hyperuricemia is a common metabolic syndrome. Elevated uric acid levels are risk factors
for gout, hypertension, and chronic kidney diseases. Furthermore, various epidemiological …

Aims/hypothesis The aim of this study was to use Mendelian randomisation (MR) to identify
the causal risk factors for type 2 diabetes. Methods We first conducted a review of meta …

OBJECTIVE To investigate whether serum uric acid (SUA) level is associated with all-cause
and cardiovascular disease (CVD) mortality among individuals with diabetes. RESEARCH …

Mendelian randomization (MR) uses genetic data to probe questions of causality in
epidemiological research, by invoking the Instrumental Variable (IV) assumptions. In recent …

Uric acid (UA) is an end product of purine metabolism in humans and great apes. UA acts as
an antioxidant and it accounts for 50% of the total antioxidant capacity of biological fluids in …

Urate is a cause of gout, kidney stones, and acute kidney injury from tumor lysis syndrome,
but its relationship to kidney disease, cardiovascular disease, and diabetes remains …

The association between uric acid (UA) on one side and systemic hypertension (Htn),
dyslipidemia, glucose intolerance, overweight, fatty liver, renal disease and cardiovascular …

Gout is the most common form of inflammatory arthritis and is a multifactorial disease
typically characterized by hyperuricemia and monosodium urate crystal deposition …

Gout, the most prevalent inflammatory arthritis worldwide, is associated with cardiovascular
and renal diseases, and is an independent predictor of premature death. The frequencies of …

Elevated serum urate levels cause gout and correlate with cardiometabolic diseases via
poorly understood mechanisms. We performed a trans-ancestry genome-wide association …