Overview of the most promising radionuclides for targeted alpha therapy: The “hopeful eight”

R Eychenne, M Chérel, F Haddad, F Guérard… - Pharmaceutics, 2021 - mdpi.com
Among all existing radionuclides, only a few are of interest for therapeutic applications and
more specifically for targeted alpha therapy (TAT). From this selection, actinium-225 …

Production, purification and availability of 211At: Near term steps towards global access

Y Feng, MR Zalutsky - Nuclear medicine and biology, 2021 - Elsevier
The promising characteristics of the 7.2-h radiohalogen 211 At have long been recognized;
including having chemical properties suitable for labeling targeting vectors ranging from …

Recent progress of astatine-211 in endoradiotherapy: Great advances from fundamental properties to targeted radiopharmaceuticals

F Li, Y Yang, J Liao, N Liu - Chinese Chemical Letters, 2022 - Elsevier
Abstract Astatine-211 (211 At, t 1/2= 7.21 h) emitting two α particles with energies of 5.87
and 7.45 MeV, can lead to a high linear energy transfer (LET= 98.84 keV/µm) and short …

Production, isolation, and shipment of clinically relevant quantities of astatine-211: A simple and efficient approach to increasing supply

LA McIntosh, JD Burns, EE Tereshatov… - Nuclear Medicine and …, 2023 - Elsevier
Abstract The alpha emitter astatine-211 (211 At) is a promising candidate for cancer
treatment based on Targeted Alpha (α) Therapy (TAT). A small number of facilities …

A new strategy for facile and rapid separation of astatine-211 from nitric acid medium

T Ye, Y Qin, W Liu, L Xia, J Liao, J Yang, T Lan… - Separation and …, 2024 - Elsevier
Developing fast and efficient separation avenues can promote either fundamental study or
practical application of astatine-211 (211 At). This work presents a new solid-phase …

Behavior of astatine and bismuth in non-conventional solvents: Extraction into imidazolium-based ionic liquid and methyl anthranilate with active pharmaceuticals …

EE Tereshatov, JD Burns, ALV Haar, SJ Schultz… - Separation and …, 2023 - Elsevier
Astatine is one of the least chemically studied elements and its behavior in the presence of
non-conventional solvents has not been investigated before. This work considers both …

Mechanism of astatine and bismuth sorption on extraction chromatography resins from nitric acid media

EE Tereshatov, JD Burns, SJ Schultz, BD Green… - Chemical Engineering …, 2023 - Elsevier
Systematic study of astatine (At) sorption on extraction chromatography resins from nitric
acid media has been performed at Texas A&M University. This work covers commercially …

Compact automated apparatus for rapid astatine recovery from nitric acid media: Design, application, and impurity characterization

EE Tereshatov, JD Burns, SJ Schultz… - Chemical Engineering …, 2022 - Elsevier
Automation of irradiated bismuth target dissolution and astatine recovery from nitric acid
media has been achieved at Texas A&M University. This process can be controlled …

Rapid recovery of At-211 by extraction chromatography

JD Burns, EE Tereshatov, G Avila, KJ Glennon… - Separation and …, 2021 - Elsevier
The near quantitative separation, purification, and recovery of 211 At has been
demonstrated through an extraction chromatography process which utilizes porous beads …

Synthesis Principle and Practice with Radioactive Iodines and Astatine: Advances Made So Far

T Dong, Z Zhang, W Li, W Zhuo, T Cui… - The Journal of Organic …, 2024 - ACS Publications
Radioactive iodines and astatine, possessing distinct exploitable nuclear properties, play
indispensable roles in the realms of nuclear imaging and therapy. Their analogous chemical …