NMDA and AMPA receptors dysregulation in Alzheimer's disease
P Babaei - European Journal of Pharmacology, 2021 - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative condition characterized by
cognitive dysfunction and synaptic failure. The current therapeutic approaches are mainly …
cognitive dysfunction and synaptic failure. The current therapeutic approaches are mainly …
Glutamate receptor ion channels: structure, regulation, and function
The mammalian ionotropic glutamate receptor family encodes 18 gene products that
coassemble to form ligand-gated ion channels containing an agonist recognition site, a …
coassemble to form ligand-gated ion channels containing an agonist recognition site, a …
Regulation of AMPA receptor trafficking and synaptic plasticity
V Anggono, RL Huganir - Current opinion in neurobiology, 2012 - Elsevier
AMPA receptors (AMPARs) mediate the majority of fast excitatory synaptic transmission in
the brain. Dynamic changes in neuronal synaptic efficacy, termed synaptic plasticity, are …
the brain. Dynamic changes in neuronal synaptic efficacy, termed synaptic plasticity, are …
The glutamate receptor ion channels
The ionotropic glutamate receptors are ligand-gated ion channels that mediate the vast
majority of excitatory neurotransmission in the brain. The cloning of cDNAs encoding …
majority of excitatory neurotransmission in the brain. The cloning of cDNAs encoding …
AMPA receptor trafficking and synaptic plasticity
R Malinow, RC Malenka - Annual review of neuroscience, 2002 - annualreviews.org
▪ Abstract Activity-dependent changes in synaptic function are believed to underlie the
formation of memories. Two prominent examples are long-term potentiation (LTP) and long …
formation of memories. Two prominent examples are long-term potentiation (LTP) and long …
Ultrastructure of synapses in the mammalian brain
KM Harris, RJ Weinberg - Cold Spring Harbor …, 2012 - cshperspectives.cshlp.org
The morphology and molecular composition of synapses provide the structural basis for
synaptic function. This article reviews the electron microscopy of excitatory synapses on …
synaptic function. This article reviews the electron microscopy of excitatory synapses on …
[HTML][HTML] Shank, a novel family of postsynaptic density proteins that binds to the NMDA receptor/PSD-95/GKAP complex and cortactin
NMDA receptors are linked to intracellular cytoskeletal and signaling molecules via the PSD-
95 protein complex. We report a novel family of postsynaptic density (PSD) proteins, termed …
95 protein complex. We report a novel family of postsynaptic density (PSD) proteins, termed …
Two-photon imaging of lymphocyte motility and antigen response in intact lymph node
MJ Miller, SH Wei, I Parker, MD Cahalan - Science, 2002 - science.org
Lymphocyte motility is vital for trafficking within lymphoid organs and for initiating contact
with antigen-presenting cells. Visualization of these processes has previously been limited …
with antigen-presenting cells. Visualization of these processes has previously been limited …
[HTML][HTML] Subunit-specific rules governing AMPA receptor trafficking to synapses in hippocampal pyramidal neurons
AMPA-type glutamate receptors (AMPA-Rs) mediate a majority of excitatory synaptic
transmission in the brain. In hippocampus, most AMPA-Rs are hetero-oligomers composed …
transmission in the brain. In hippocampus, most AMPA-Rs are hetero-oligomers composed …
[HTML][HTML] AMPA receptor trafficking at excitatory synapses
DS Bredt, RA Nicoll - Neuron, 2003 - cell.com
Excitatory synapses in the CNS release glutamate, which acts primarily on two types of
ionotropic receptors: AMPA receptors and NMDA receptors. AMPA receptors mediate the …
ionotropic receptors: AMPA receptors and NMDA receptors. AMPA receptors mediate the …