The anti-VEGF (R) drug discovery legacy: improving attrition rates by breaking the vicious cycle of angiogenesis in cancer

D Ribatti, AG Solimando, F Pezzella - Cancers, 2021 - mdpi.com
Simple Summary Several anti-angiogenic drugs have been approved for cancer treatment,
alone or in combination with other anti-tumoral agents. Angiogenesis inhibitors cause drug …

[HTML][HTML] The importance of immune checkpoints in immune monitoring: A future paradigm shift in the treatment of cancer

H Alemohammad, B Najafzadeh, Z Asadzadeh… - Biomedicine & …, 2022 - Elsevier
The growth and development of cancer are directly correlated to the suppression of the
immune system. A major breakthrough in cancer immunotherapy depends on various …

Targeting tumor immunosuppressive microenvironment for pancreatic cancer immunotherapy: Current research and future perspective

Y Li, S Xiang, W Pan, J Wang, H Zhan, S Liu - Frontiers in Oncology, 2023 - frontiersin.org
Pancreatic cancer is one of the most malignant tumors with increased incidence rate. The
effect of surgery combined with chemoradiotherapy on survival of patients is unsatisfactory …

Mast cells and interleukins

AG Solimando, V Desantis, D Ribatti - International Journal of Molecular …, 2022 - mdpi.com
Mast cells play a critical role in inflammatory diseases and tumor growth. The versatility of
mast cells is reflected in their ability to secrete a wide range of biologically active cytokines …

Targeted therapy for pancreatic ductal adenocarcinoma: Mechanisms and clinical study

HC Kung, J Yu - MedComm, 2023 - Wiley Online Library
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive and lethal malignancy with a
high rate of recurrence and a dismal 5‐year survival rate. Contributing to the poor prognosis …

Pancreatic cancer: challenges and opportunities in locoregional therapies

AY Bazeed, CM Day, S Garg - Cancers, 2022 - mdpi.com
Simple Summary Pancreatic cancer is a serious ongoing global health burden, with an
overall 5-year survival rate of less than 5%. One major hurdle in the treatment of this disease …

NAT10-mediated AXL mRNA N4-acetylcytidine modification promotes pancreatic carcinoma progression

G Zong, X Wang, X Guo, Q Zhao, C Wang… - Experimental Cell …, 2023 - Elsevier
Although the patient's survival time in various cancers has significantly increased in recent
decades, the overall 5-year survival rate of pancreatic ductal adenocarcinoma (PDAC) has …

Clinical strategies targeting the tumor microenvironment of pancreatic ductal adenocarcinoma

N Skorupan, M Palestino Dominguez, SL Ricci… - Cancers, 2022 - mdpi.com
Simple Summary Tumors from pancreatic cancer contain many types of cells (such as
immune cells and fibroblasts) in addition to the cancer cells. Using targeted drugs to disrupt …

Unraveling the gut microbiome's contribution to pancreatic ductal adenocarcinoma: mechanistic insights and therapeutic perspectives

E Tabrizi, F Pourteymour Fard Tabrizi… - Frontiers in …, 2024 - frontiersin.org
The gut microbiome plays a significant role in the pathogenesis of pancreatic ductal
adenocarcinoma (PDAC), influencing oncogenesis, immune responses, and treatment …

[HTML][HTML] The regulatory role of autophagy-related miRNAs in lung cancer drug resistance

M Shahverdi, K Hajiasgharzadeh, AD Sorkhabi… - Biomedicine & …, 2022 - Elsevier
Autophagy is conserved cellular machinery that degrades un-usable proteins and cellular
components and has a crucial role in the pathogenesis and drug resistance of various …