Bacterial stress responses during host infection

FC Fang, ER Frawley, T Tapscott, A Vázquez-Torres - Cell host & microbe, 2016 - cell.com
Pathogenic bacteria must withstand diverse host environments during infection.
Environmental signals, such as pH, temperature, nutrient limitation, etc., not only trigger …

How the PhoP/PhoQ System Controls Virulence and Mg2+ Homeostasis: Lessons in Signal Transduction, Pathogenesis, Physiology, and Evolution

EA Groisman, A Duprey, J Choi - Microbiology and Molecular …, 2021 - Am Soc Microbiol
SUMMARY The PhoP/PhoQ two-component system governs virulence, Mg2+ homeostasis,
and resistance to a variety of antimicrobial agents, including acidic pH and cationic …

Trouble is coming: Signaling pathways that regulate general stress responses in bacteria

S Gottesman - Journal of Biological Chemistry, 2019 - ASBMB
Bacteria can rapidly and reversibly respond to changing environments via complex
transcriptional and post-transcriptional regulatory mechanisms. Many of these adaptations …

AAA+ proteases: ATP-fueled machines of protein destruction

RT Sauer, TA Baker - Annual review of biochemistry, 2011 - annualreviews.org
AAA+ family proteolytic machines (ClpXP, ClpAP, ClpCP, HslUV, Lon, FtsH, PAN/20S, and
the 26S proteasome) perform protein quality control and are used in regulatory circuits in all …

Salmonella biofilms: an overview on occurrence, structure, regulation and eradication

H Steenackers, K Hermans, J Vanderleyden… - Food research …, 2012 - Elsevier
The ability of Salmonella to form complex surface-associated communities, called biofilms,
contributes to its resistance and persistence in both host and non-host environments and is …

Antibacterial effects of carbon nanotubes: size does matter!

S Kang, M Herzberg, DF Rodrigues, M Elimelech - Langmuir, 2008 - ACS Publications
We provide the first evidence that the size (diameter) of carbon nanotubes (CNTs) is a key
factor governing their antibacterial effects and that the likely main CNT-cytotoxicity …

The RpoS-Mediated General Stress Response in Escherichia coli

A Battesti, N Majdalani… - Annual review of …, 2011 - annualreviews.org
Under conditions of nutrient deprivation or stress, or as cells enter stationary phase,
Escherichia coli and related bacteria increase the accumulation of RpoS, a specialized …

Polymyxin: alternative mechanisms of action and resistance

MJ Trimble, P Mlynárčik… - Cold Spring …, 2016 - perspectivesinmedicine.cshlp.org
Antibiotic resistance among pathogenic bacteria is an ever-increasing issue worldwide.
Unfortunately, very little has been achieved in the pharmaceutical industry to combat this …

Mutation as a stress response and the regulation of evolvability

RS Galhardo, PJ Hastings… - Critical reviews in …, 2007 - Taylor & Francis
Our concept of a stable genome is evolving to one in which genomes are plastic and
responsive to environmental changes. Growing evidence shows that a variety of …

Signal integration in bacterial two-component regulatory systems

AY Mitrophanov, EA Groisman - Genes & development, 2008 - genesdev.cshlp.org
Two-component systems (TCSs) and phosphorelays are key mediators of bacterial signal
transduction. The signals activating these systems promote the phosphorylated state of a …