Phosphorylation signaling in APP processing in Alzheimer's disease
T Zhang, D Chen, TH Lee - International journal of molecular sciences, 2019 - mdpi.com
The abnormal accumulation of amyloid-β (Aβ) in the central nervous system is a hallmark of
Alzheimer's disease (AD). The regulation of the processing of the single-transmembrane …
Alzheimer's disease (AD). The regulation of the processing of the single-transmembrane …
Targeting Alzheimer's disease: the critical crosstalk between the liver and brain
Alzheimer's disease (AD), an age-related neurodegenerative disorder, is currently incurable.
Imbalanced amyloid-beta (Aβ) generation and clearance are thought to play a pivotal role in …
Imbalanced amyloid-beta (Aβ) generation and clearance are thought to play a pivotal role in …
Semaglutide ameliorates cognition and glucose metabolism dysfunction in the 3xTg mouse model of Alzheimer's disease via the GLP-1R/SIRT1/GLUT4 pathway
ZJ Wang, XR Li, SF Chai, WR Li, S Li, M Hou, JL Li… - …, 2023 - Elsevier
Disorders of brain glucose metabolism is known to affect brain activity in neurodegenerative
diseases including Alzheimer's disease (AD). Furthermore, recent evidence has shown an …
diseases including Alzheimer's disease (AD). Furthermore, recent evidence has shown an …
Amyloid‐β impairs the phagocytosis of dystrophic synapses by astrocytes in Alzheimer's disease
MV Sanchez‐Mico, S Jimenez, A Gomez‐Arboledas… - Glia, 2021 - Wiley Online Library
Reactive astrocytes and dystrophic neurites, most aberrant presynaptic elements, are found
surrounding amyloid‐β plaques in Alzheimer's disease (AD). We have previously shown that …
surrounding amyloid‐β plaques in Alzheimer's disease (AD). We have previously shown that …
Mitochondrial abnormalities in neurodegenerative models and possible interventions: Focus on Alzheimer's disease, Parkinson's disease, Huntington's disease
P Pantiya, C Thonusin, N Chattipakorn… - Mitochondrion, 2020 - Elsevier
Mitochondrial abnormalities in the brain are considered early pathological changes in
neurogenerative diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD) and …
neurogenerative diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD) and …
Alzheimer's disease: recent concepts on the relation of mitochondrial disturbances, excitotoxicity, neuroinflammation, and kynurenines
The pathomechanism of Alzheimer's disease (AD) certainly involves mitochondrial
disturbances, glutamate excitotoxicity, and neuroinflammation. The three main aspects of …
disturbances, glutamate excitotoxicity, and neuroinflammation. The three main aspects of …
Salvianolic acid B ameliorates retinal deficits in an early-stage alzheimer's disease mouse model through downregulating bace1 and Aβ Generation
M Wang, S Zhang, X Liu, P Wang, Y Zhu… - Acta Pharmacologica …, 2023 - nature.com
Alzheimer's disease (AD) is a neurodegenerative disease with subtle onset, early diagnosis
remains challenging. Accumulating evidence suggests that the emergence of retinal …
remains challenging. Accumulating evidence suggests that the emergence of retinal …
Nanosensor-Driven Detection of Neuron-Derived Exosomal Aβ42 with Graphene Electrolyte-Gated Transistor for Alzheimer's Disease Diagnosis
Blood-based tests have sparked tremendous attention in non-invasive early diagnosis of
Alzheimer's disease (AD), a most prevalent neurodegenerative malady worldwide. Despite …
Alzheimer's disease (AD), a most prevalent neurodegenerative malady worldwide. Despite …
[HTML][HTML] Shaping the risk for late-life neurodegenerative disease: A systematic review on prenatal risk factors for Alzheimer's disease-related volumetric brain …
Environmental exposures including toxins and nutrition may hamper the developing brain in
utero, limiting the brain's reserve capacity and increasing the risk for Alzheimer's disease …
utero, limiting the brain's reserve capacity and increasing the risk for Alzheimer's disease …
Therapeutic potential of ursolic acid in cancer and diabetic neuropathy diseases
Ursolic acid (UA) is a pentacyclic triterpenoid frequently found in medicinal herbs and plants,
having numerous pharmacological effects. UA and its analogs treat multiple diseases …
having numerous pharmacological effects. UA and its analogs treat multiple diseases …