Phosphorylation signaling in APP processing in Alzheimer's disease

T Zhang, D Chen, TH Lee - International journal of molecular sciences, 2019 - mdpi.com
The abnormal accumulation of amyloid-β (Aβ) in the central nervous system is a hallmark of
Alzheimer's disease (AD). The regulation of the processing of the single-transmembrane …

Targeting Alzheimer's disease: the critical crosstalk between the liver and brain

Z Huang, HW Lin, Q Zhang, X Zong - Nutrients, 2022 - mdpi.com
Alzheimer's disease (AD), an age-related neurodegenerative disorder, is currently incurable.
Imbalanced amyloid-beta (Aβ) generation and clearance are thought to play a pivotal role in …

Semaglutide ameliorates cognition and glucose metabolism dysfunction in the 3xTg mouse model of Alzheimer's disease via the GLP-1R/SIRT1/GLUT4 pathway

ZJ Wang, XR Li, SF Chai, WR Li, S Li, M Hou, JL Li… - …, 2023 - Elsevier
Disorders of brain glucose metabolism is known to affect brain activity in neurodegenerative
diseases including Alzheimer's disease (AD). Furthermore, recent evidence has shown an …

Amyloid‐β impairs the phagocytosis of dystrophic synapses by astrocytes in Alzheimer's disease

MV Sanchez‐Mico, S Jimenez, A Gomez‐Arboledas… - Glia, 2021 - Wiley Online Library
Reactive astrocytes and dystrophic neurites, most aberrant presynaptic elements, are found
surrounding amyloid‐β plaques in Alzheimer's disease (AD). We have previously shown that …

Mitochondrial abnormalities in neurodegenerative models and possible interventions: Focus on Alzheimer's disease, Parkinson's disease, Huntington's disease

P Pantiya, C Thonusin, N Chattipakorn… - Mitochondrion, 2020 - Elsevier
Mitochondrial abnormalities in the brain are considered early pathological changes in
neurogenerative diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD) and …

Alzheimer's disease: recent concepts on the relation of mitochondrial disturbances, excitotoxicity, neuroinflammation, and kynurenines

D Zádori, G Veres, L Szalárdy… - Journal of Alzheimer's …, 2018 - content.iospress.com
The pathomechanism of Alzheimer's disease (AD) certainly involves mitochondrial
disturbances, glutamate excitotoxicity, and neuroinflammation. The three main aspects of …

Salvianolic acid B ameliorates retinal deficits in an early-stage alzheimer's disease mouse model through downregulating bace1 and Aβ Generation

M Wang, S Zhang, X Liu, P Wang, Y Zhu… - Acta Pharmacologica …, 2023 - nature.com
Alzheimer's disease (AD) is a neurodegenerative disease with subtle onset, early diagnosis
remains challenging. Accumulating evidence suggests that the emergence of retinal …

Nanosensor-Driven Detection of Neuron-Derived Exosomal Aβ42 with Graphene Electrolyte-Gated Transistor for Alzheimer's Disease Diagnosis

J Li, W Ni, D Jin, Y Yu, MM Xiao, ZY Zhang… - Analytical …, 2023 - ACS Publications
Blood-based tests have sparked tremendous attention in non-invasive early diagnosis of
Alzheimer's disease (AD), a most prevalent neurodegenerative malady worldwide. Despite …

[HTML][HTML] Shaping the risk for late-life neurodegenerative disease: A systematic review on prenatal risk factors for Alzheimer's disease-related volumetric brain …

A Boots, AM Wiegersma, Y Vali, M van den Hof… - Neuroscience & …, 2023 - Elsevier
Environmental exposures including toxins and nutrition may hamper the developing brain in
utero, limiting the brain's reserve capacity and increasing the risk for Alzheimer's disease …

Therapeutic potential of ursolic acid in cancer and diabetic neuropathy diseases

M Alam, S Ali, S Ahmed, AM Elasbali, M Adnan… - International journal of …, 2021 - mdpi.com
Ursolic acid (UA) is a pentacyclic triterpenoid frequently found in medicinal herbs and plants,
having numerous pharmacological effects. UA and its analogs treat multiple diseases …