The abnormal accumulation of amyloid-β (Aβ) in the central nervous system is a hallmark of
Alzheimer's disease (AD). The regulation of the processing of the single-transmembrane …

Alzheimer's disease (AD), an age-related neurodegenerative disorder, is currently incurable.
Imbalanced amyloid-beta (Aβ) generation and clearance are thought to play a pivotal role in …

Disorders of brain glucose metabolism is known to affect brain activity in neurodegenerative
diseases including Alzheimer's disease (AD). Furthermore, recent evidence has shown an …

Reactive astrocytes and dystrophic neurites, most aberrant presynaptic elements, are found
surrounding amyloid‐β plaques in Alzheimer's disease (AD). We have previously shown that …

Mitochondrial abnormalities in the brain are considered early pathological changes in
neurogenerative diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD) and …

The pathomechanism of Alzheimer's disease (AD) certainly involves mitochondrial
disturbances, glutamate excitotoxicity, and neuroinflammation. The three main aspects of …

Alzheimer's disease (AD) is a neurodegenerative disease with subtle onset, early diagnosis
remains challenging. Accumulating evidence suggests that the emergence of retinal …

Blood-based tests have sparked tremendous attention in non-invasive early diagnosis of
Alzheimer's disease (AD), a most prevalent neurodegenerative malady worldwide. Despite …

Environmental exposures including toxins and nutrition may hamper the developing brain in
utero, limiting the brain's reserve capacity and increasing the risk for Alzheimer's disease …

Ursolic acid (UA) is a pentacyclic triterpenoid frequently found in medicinal herbs and plants,
having numerous pharmacological effects. UA and its analogs treat multiple diseases …